ID   R6DDH4_9FIRM            Unreviewed;       888 AA.
AC   R6DDH4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Sulfatase {ECO:0000313|EMBL:CDA82271.1};
GN   ORFNames=BN516_00821 {ECO:0000313|EMBL:CDA82271.1};
OS   Firmicutes bacterium CAG:176.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263007 {ECO:0000313|EMBL:CDA82271.1, ECO:0000313|Proteomes:UP000017932};
RN   [1] {ECO:0000313|EMBL:CDA82271.1, ECO:0000313|Proteomes:UP000017932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:176 {ECO:0000313|Proteomes:UP000017932};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004936}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA82271.1}.
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DR   EMBL; CBCO010000189; CDA82271.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6DDH4; -.
DR   Proteomes; UP000017932; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.30.1120.170; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017932};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        38..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        66..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          330..597
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   888 AA;  99966 MW;  C5B37186849C9DE4 CRC64;
     MLKTKSNEIT DTHQAPCEAP ETAEALRRSM WQAWLRSLLL FCGASVYVEL CLHLCVYRSL
     DRRAVYLVLF GLLGGTVCAL LTTHLPKIAR QIVGVLLVAV QVLFAEVQLM YHAIFGNFMP
     ISQVSMGGNV ITNFDSQILY SIGKNIVPIL LLLVPLIVTI LCLALRKLRV LTVRLKWRQA
     LATLGILLTL LLATMGIMYA GRGKSFSVYK TFTNVNTSTD SSYKSVGMLA TTVQELRYMV
     FGSSGSVIIT PSPLGTDTRR LYSSNSYNVI ESIDFAKLAE SADNIMCRTT DEYLAQVVPT
     RKNNYTGLLQ DYNLITICAE SFCPWFISEE LTPTLYKLSH TGIIFENYYG TFQSVTTNGE
     YTMCMGLYPD MSRTKTDSSF NVAGTNYLPF CLGNALTEKG YQTWGYHDYI GDFYNRNITH
     ANMGYTFKAA DSGLDIKIDW PSSDLEMMEA SVDDYLSSRE PFHAYYMTFS GHYQYNWDNA
     MSAKNHDAVK DLPYSEPVKA YIACNLELEN ALTYLLQRLE QAGVADKTCI VLTNDHYPYG
     LTEDEYNELA GQEMDLTFEK YRNSFICYVP GLSENIVVDE YCSTADILPT LLNLFGVDYD
     SRLLAGTDVL SNGVHMAVLS DKSFLTKTFR YNAGTETVIP ADESVVISDE QLEAYRLYVD
     NKFQMSSNIV NSDYYAHVFG KASSGGTLED TVVFTDITGI FNQASVLYMY RNGYIDPETP
     DTFGGKATAK VGEFVDVLYR ISQRPETDNT ALPPDYENET FNGSACPYYD AVCWAYQTGL
     LRQGDLHTAY DDDMDYQTAC LLIYRYAAMS GIDTRVDQEL LRQTMWGNPR LSGEVVKAML
     WCDDRDITTR DSGLSELLAA YDTHISRYQM TSFLFYLCTY ELNSRNEA
//