ID   R6DEX9_9BACE            Unreviewed;       756 AA.
AC   R6DEX9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Alpha-1 2-mannosidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN772_01287 {ECO:0000313|EMBL:CDA82791.1};
OS   Bacteroides sp. CAG:754.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1262750 {ECO:0000313|EMBL:CDA82791.1, ECO:0000313|Proteomes:UP000017906};
RN   [1] {ECO:0000313|EMBL:CDA82791.1, ECO:0000313|Proteomes:UP000017906}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:754 {ECO:0000313|Proteomes:UP000017906};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA82791.1}.
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DR   EMBL; CBCP010000034; CDA82791.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6DEX9; -.
DR   Proteomes; UP000017906; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 1.20.1050.60; alpha-1,2-mannosidase; 1.
DR   Gene3D; 1.20.1610.10; alpha-1,2-mannosidases domains; 1.
DR   Gene3D; 3.30.2080.10; GH92 mannosidase domain; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR005887; GH92_a_mannosidase_put.
DR   InterPro; IPR041371; GH92_N.
DR   InterPro; IPR012939; Glyco_hydro_92.
DR   NCBIfam; TIGR01180; aman2_put; 1.
DR   PANTHER; PTHR12143; PEPTIDE N-GLYCANASE PNGASE -RELATED; 1.
DR   PANTHER; PTHR12143:SF39; SECRETED PROTEIN-RELATED; 1.
DR   Pfam; PF07971; Glyco_hydro_92; 1.
DR   Pfam; PF17678; Glyco_hydro_92N; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017906};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..756
FT                   /note="Alpha-1 2-mannosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004415455"
FT   DOMAIN          35..265
FT                   /note="Glycosyl hydrolase family 92 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17678"
FT   DOMAIN          271..734
FT                   /note="Glycosyl hydrolase family 92"
FT                   /evidence="ECO:0000259|Pfam:PF07971"
SQ   SEQUENCE   756 AA;  85516 MW;  0AC8A847C0E17CEE CRC64;
     MKAFKLLALT SCFLLAAGNG VAQRDYSKSE GLLRYVDPYI GSGYHGHVFV GTSVPYGMVQ
     LGPNNIHKGW DWCSGYHYSD SILIGFSHTH LSGTGCTDLG DILIMPLNEI RTPRGNQDDI
     RDGYASRYSH DNEIARPEYY SLLLDRYDIK AELTATDRVG FHRYTYPDGK PASILIDLRE
     GNGSNAYDSY IRKIDDYTVE GYRYVRGWSP SRKVYFVLKS DKKIEQFTAY DDNTPKPWNQ
     LKVASVKSVL TFGYEKEVKV KVAISSVSCA NALMNLQAEL SHWDFDKTVK MSADRWNKQL
     ARMSVETDNE PAKRIFYTAH YHTMIAPTLY CDVNGEYRGM NDMIYTDPKK ANYTTLSLWD
     TYRALHPLMT IVQPEMVDNV VNSMLSIYHQ QDKLPIWPLM SGETNCMPGY SSVPVIADAY
     LKGFTGFDAE EALQAMKATA TYEKQKGIPH VLEKEYIPAD KVHEATSIAM EYAVDDWGIA
     AMAHKMGKYE DAATYAKRAH YYKNYFDSSI HFIRPKLEDG SWRTPYDPAR SIHTVGDFCE
     GNGWQYTFFA PQDPYGLIGL FGGDKPFTAK LDNFFTNNDS MGEGASSDIT GLIGQYAHGN
     EPSHHVAYLY AYAGEQWKTA EKVRFIMDEF YTDKPDGIIG NEDCGQMSAW YLLSSMGLYQ
     VNPSDGIFVF GSPCFKKVEM KVRGGKTFTV EAPNNNKENI YIQKVYLNGK PYNKSYITYD
     DIINGSTLKF VMGKKPNKNF GKAPANRPVV LNKINE
//