ID R6DFZ2_9BACE Unreviewed; 1014 AA.
AC R6DFZ2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=BN772_01612 {ECO:0000313|EMBL:CDA83131.1};
OS Bacteroides sp. CAG:754.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262750 {ECO:0000313|EMBL:CDA83131.1, ECO:0000313|Proteomes:UP000017906};
RN [1] {ECO:0000313|EMBL:CDA83131.1, ECO:0000313|Proteomes:UP000017906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:754 {ECO:0000313|Proteomes:UP000017906};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA83131.1}.
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DR EMBL; CBCP010000059; CDA83131.1; -; Genomic_DNA.
DR AlphaFoldDB; R6DFZ2; -.
DR Proteomes; UP000017906; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000017906}.
FT DOMAIN 44..203
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 206..316
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 319..606
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 1014 AA; 116335 MW; 800CF2A366070CA3 CRC64;
MYKLNLMNQY FALFLLLIFP VLSIAQELEI PKQSVYQVRD KMELQTLNGK WKFKYIENKN
IPSSLSGFVE SNFDDSTWDY ITVPSNWETE GFKTPQYGAD IVESWGLYRT TFKANPVWKN
RHVILRFDGV QFGYEVYVNG HYAGRWGSSF NPCQFDITSF LHFDRPNVLA VKVSTRTKGW
RFDLNDCWAL AGIFRDVELF SVPNLHLKDV TFVSKLEGNE RAALTFNVDV AAFKTLDDSE
QYRAQVLFYD KTGRHLFSSS QPIVLKENGQ LLQFDWRLQN PHLWTAETPY LYRMEVRIMD
SRNSVVQQIS ENVGVREVLV KDGILLVNNT PVLLRGTCHN EIDPVHGRAL TTADRLKQLQ
MMKAANVNFI RTAHYPFHPE FHKMCDEMGF YVCCEVPFGY GDSNLYKEEY TTELCTRAEA
TLTRDKNHPS IIMWTIGNEN PYTEVVEKVV QYVKQKDPTR PRALPMAGNY FLENRERLSD
NLDIYAFHYQ SAQTVARIAD LKQKPVITTE YSHALGLAFD ALESQFDTIL SRKNIAGGAV
WCWSDQALLR NRTKNDFMCD SVPMGVWLDS LRYLDSYNDK GTDGIVYADG YPQEDYWQLR
KIYSPIVVLD KEFGIHEGKQ IIELTVENRF NFISLVGYRC NWQIRNLSKE LGNGSVQLSA
LAGQQEKISL QCILPADIEN NDCMLYLEVT DNRGAPVYEK SIPLLVDNQR PDYLKLVGHL
PEQKRFRIQK SSAMLSVQGE DYLFAVDKNG KLTIQDTDKR KVMDTYLYLR VGRKPSINIV
NFLMRKKTFG WEPYLLTPEV KKFDCMEEKG KVSARLHCRW SRVDKAGEYI EGDVIFSVTK
NGVMTVDYDL VPYHTTGTLW ECGPTFALHP SIETFRWLGN GPYTSTPGKT AYNERDTWAL
HKDDMHFMGN RGLVDAAVLL DNENKGIGYI GSSSDLAVEK IGDAIYITDN AIVSSYGTKL
SQPVVNNKAD KVKNIKGKFN LMLVGKAGNM LLTPLFSPYS EVLPNMHFLK SYGH
//
