ID   R6DX62_9FIRM            Unreviewed;      1405 AA.
AC   R6DX62;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=CoA-substrate-specific enzyme activase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN553_00893 {ECO:0000313|EMBL:CDA89479.1};
OS   Firmicutes bacterium CAG:238.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263011 {ECO:0000313|EMBL:CDA89479.1, ECO:0000313|Proteomes:UP000018260};
RN   [1] {ECO:0000313|EMBL:CDA89479.1, ECO:0000313|Proteomes:UP000018260}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:238 {ECO:0000313|Proteomes:UP000018260};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA89479.1}.
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DR   EMBL; CBCS010000015; CDA89479.1; -; Genomic_DNA.
DR   Proteomes; UP000018260; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018260}.
FT   DOMAIN          3..250
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          318..570
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          668..887
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1405 AA;  155862 MW;  D2EC3F84B04079D0 CRC64;
     MRLGIDVGST TVKLVLIDDN GKILYQRYER HMSSVFSKVS ELLEQMRAEV GDIAVKAVIT
     GSGGLSLADK IGARFEQEVV TCSLAVEKLI PQTDVVIELG GEDAKITYFG STIEQRMNGT
     CAGGTGAFID QMAILLNTDG DGLNEAAKDY SIIYPIAARC GVFAKTDIQP LINEGAPIEN
     LAASIFQAVV NQTISGLACG HKIKGNVAFL GGPLTYLSEL RKRFIETLEL KPEEVIFPEN
     SKYFVAIGAA YMTDGEQEVK LSELLDRVNS VDPLADSATK HVEPLFKDEA EYRAFKERHA
     KAQIKRKELR SCKGPLFLGI DAGSTTTKAA LIDQDKNLVY SFYRNNEGNP LEATKLMLNE
     LYCMLPADTY IANATVTGYG EGLIKAAFRA DYGIIETMAH YKAAEEFLPG VDFILDIGGQ
     DMKCMKIKDH AIYSIMLNEA CSSGCGSFIE TYAKSVDMPV EEFAQIGLMS QNPVDLGTRC
     TVFMNSMVKQ AQKEGASIGD IAAGLSYSVI KNALYKVIKL RNPDEAGDKI VVQGGTFLNE
     SVLRAIEKVL GKDVVRPDIA GIMGAYGCAL NSMNNWKYGH KSSLLDFDAV KAFTAGSSNA
     RCNGCENRCM LTITKFNDNE RYITGNRCEK GSGKVGTASE LPDLYEYKLK RLFGYEPLEA
     SEAPRGSVAI PRVLNMYEDY PFWFTFFTKL GFRVVLSPMS SKELYEKGIE SISSDTACYP
     AKLVHGHIQT LVEMGEKWIF YPCVNYEQVE DESAQNHYNC PIVATYPEVI ANNMNDVFEE
     NGVKFSHPFV PYDNDERLIK RMYEILQAKG IGKAEIASAV HAARKEQHAF KCDVENEGRK
     ALAYAKEHKK KAIILAGRPY HLDTEINHGI NKMITSFDMV VLSEDSVCGM GNLPRPIRVL
     DQWVYHSRLY KAADFAGRTD GVELVQLNSF GCGVDAVTTD EVEEILEHSN KLYTVLKIDE
     GNNLGAIRIR IRSLKAAMEE RDKNGIKAKH SEKPFERRLF TEEMRKNYTL LIPQMSPIHF
     QYLEVALRES GYNAVLIPTV DKHAIDEGLK YVNNDACYPT LVTLGKMISA LKSGDYDLDR
     TALIMSQTGG GCRASNYIAL LRKALKDLNM EQVPVVSFNM VGLETNPGFK IDVSMGKRLV
     MAAVYGDLFQ RLLYATRPYE EVPGSAEAIM KKYEAAIFQN CKDGKLSTYK KLIPQIVADY
     DALPLKDIKK PKVGVVGEIL VKYHPDANNN IVDIIEKEGG EAVVLDLIDF FLYGMYSKKF
     NYEKLSGSYK QYKVNQAGIA LIEWFRKPMR QALRKSKRFT QPGYIEKTAE EASVIASTGN
     QCGEGWLLTG EMIELIKSGV PNIACLQPFA CLPNHVTGKG MMKAIRERFP KANIVAIDYD
     PGASNVNQLN RIKLMMATAH KNLEA
//