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Database: UniProt
Entry: R6ECX0_9FIRM
LinkDB: R6ECX0_9FIRM
Original site: R6ECX0_9FIRM 
ID   R6ECX0_9FIRM            Unreviewed;       736 AA.
AC   R6ECX0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|ARBA:ARBA00031200, ECO:0000256|RuleBase:RU362098};
GN   ORFNames=BN538_01050 {ECO:0000313|EMBL:CDA97710.1};
OS   Lachnospiraceae bacterium CAG:215.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1262985 {ECO:0000313|EMBL:CDA97710.1, ECO:0000313|Proteomes:UP000018007};
RN   [1] {ECO:0000313|EMBL:CDA97710.1, ECO:0000313|Proteomes:UP000018007}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:215 {ECO:0000313|Proteomes:UP000018007};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake system.
CC       {ECO:0000256|ARBA:ARBA00003926, ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362098};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU362098}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA97710.1}.
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DR   EMBL; CBCV010000117; CDA97710.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6ECX0; -.
DR   Proteomes; UP000018007; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   Gene3D; 1.10.287.1770; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   NCBIfam; TIGR00437; feoB; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43185:SF1; FE(2+) TRANSPORTER FEOB; 1.
DR   PANTHER; PTHR43185; FERROUS IRON TRANSPORT PROTEIN B; 1.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PIRSR:PIRSR603373-
KW   1}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|ARBA:ARBA00022496,
KW   ECO:0000256|RuleBase:RU362098};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR603373-2};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362098};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR603373-2};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRSR:PIRSR603373-1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM        298..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        365..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        412..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        441..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        529..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        567..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        591..614
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        634..653
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        665..688
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   TRANSMEM        694..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362098"
FT   DOMAIN          14..179
FT                   /note="FeoB-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51711"
FT   BINDING         21..28
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         32
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         33
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         35
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         36
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-2"
FT   BINDING         46..50
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         70..73
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
FT   BINDING         130..133
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603373-1"
SQ   SEQUENCE   736 AA;  80581 MW;  10C591855999FF05 CRC64;
     MFQHSDEKER IKMRVKIALV GNPNSGKTTL FNALTGSNQF VGNWPGVTVE KKEGKIKGYT
     SKAEEAILVD LPGVYSLSPY TLEEVVSRNF LIGEKPDAII NIIDGTNLER NLYLTTQLTE
     LGIPVIVAVN MMDLVRKNGE VLDIEKLGKD IGCKVVEISA LRGEGIDQLA QRAVAIARGK
     KKNQPAHRFD GCVEHALAHI EEAIAGRVDE SMERWYAVKL FERDEKVRES LDLDPALIRH
     IEEDIVSCET EMDDDAESII TGERYNYIGN IIEDCYKKRV KKTMSTSDKI DSIVTNRFLA
     LPIFAAVMFL VYYVSVTTVG TLLTDWTNDT LFGAWIIPGA QSVLEAIGCA PWLTGLLVDG
     IISGVGAVLG FVPQMLVLFL FLAFLEGCGY MARIAFIMDR IFRKFGLSGK SFIPMLIGTG
     CGVPGVMASR TIENDRDRKM TIMTTTFIPC GAKLPIIALI AGALFGGASW VAPSAYFVGI
     AAIICSGIIL KKTKMFAGDP APFVMELPAY HLPTVGNVLR STWERGWSFI KKAGTIILLS
     TIFIWFAQSF GFEGGTFKMV ENMENSILAA IGSGIAWIFT PLGWGNWKPA VAAITGLVAK
     ENVVGTFGIL YGFGEVAEDG AEIWGTLSGA MTQAAAYSFL VFNLLCAPCF AAMGAIKREM
     NNAKWFWFAI GYQTLLAYTV SLCVYQIGTW VSTGLFGAGT IAALILIAAF LWLLFRPYQE
     NRMRKMSQNA AGEAKV
//
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