ID R6EWC4_9BACT Unreviewed; 834 AA.
AC R6EWC4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Tyrosine-protein kinase {ECO:0000313|EMBL:CDA94217.1};
GN ORFNames=BN487_00842 {ECO:0000313|EMBL:CDA94217.1};
OS Prevotella sp. CAG:1320.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262922 {ECO:0000313|EMBL:CDA94217.1, ECO:0000313|Proteomes:UP000018111};
RN [1] {ECO:0000313|EMBL:CDA94217.1, ECO:0000313|Proteomes:UP000018111}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:1320 {ECO:0000313|Proteomes:UP000018111};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA94217.1}.
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DR EMBL; CBCU010000037; CDA94217.1; -; Genomic_DNA.
DR AlphaFoldDB; R6EWC4; -.
DR STRING; 1262922.BN487_00842; -.
DR Proteomes; UP000018111; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDA94217.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018111};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 36..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..117
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 460..533
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 602..727
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 298..355
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 834 AA; 93403 MW; 8A51D233B83D0875 CRC64;
MEENKNYTSI SQENAEENST FDFNTIFTML ILNWKWFVLS IIICLGLAVV YLKLATPKYQ
VYAKFLIKDE ENNKLGGAGS SLLNETSLGF ITNSNGFDNE MEILGSRMLS INVIKELKLY
TSYYKANGLK DSILYRTQPI TVEIDSAHLA KLGNAKIHLT ITKWENGYEV EGAYTTPLQE
GAVGEEVEVN HNFTKLPATL KTRAGILTLK DNGLAMEVGD KEKVDIISPE SMADIYMKQM
SAEQTSKTTT IAQLTLTETS RSRAQDYLNQ LALCYNEQAN EDKNEIAIRT EAFINSRLEK
INAELGVTEG SLEKYKKQNR VVELQLNAES AITNAEQFSQ KLAQAETQLA LLASLKEYME
EPHNKYQTLP SNVGLTDESA TQLIAKYNEI VLERNRLLRT ASESSPSVLP LTSQLDHLYT
SIQRAMEQSR RSLRIERDNI ASQFGKYQGQ VGQTPEQERT LNEIGRQQEV RSGLYLMLLQ
KREENSINLA ATADKGKLID GPTVEGKVSP KTSIILMVAL VLGLGIPFGI LFLLEFFRYK
IDGHEDVEKL TKLPILGDVA VASESAKGRA EIVVHENVNN MMEEIFRSMR TNLQFMLKEG
EKTIMFTSST SGEGKTFVAS NLAICFALLG KKVVLIGLDI RKPRLADLFR IDNKHTGITN
LLVKSNVTWE DIQKQILPSE VNANMDLLMA GPVPPNPAEL LSRPTLDKIF EILREHYDYI
LVDTAPVGLV TDTLHISRVA NITAYVTRAD YTPKENILMV NKLAEDGKLP NVSIIINGID
MSLNKNSFRY GYGKYGKYGK YGHYGHYGHY GSYGSYGNYS NSHYGNANDN SIKK
//
