ID   R6EX52_9BACT            Unreviewed;       729 AA.
AC   R6EX52;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   SubName: Full=Glutamate--ammonia ligase catalytic domain protein {ECO:0000313|EMBL:CDB05273.1};
GN   ORFNames=BN691_02101 {ECO:0000313|EMBL:CDB05273.1};
OS   Prevotella sp. CAG:520.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262929 {ECO:0000313|EMBL:CDB05273.1, ECO:0000313|Proteomes:UP000018359};
RN   [1] {ECO:0000313|EMBL:CDB05273.1, ECO:0000313|Proteomes:UP000018359}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:520 {ECO:0000313|Proteomes:UP000018359};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01330, ECO:0000256|RuleBase:RU000384}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB05273.1}.
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DR   EMBL; CBCY010000115; CDB05273.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6EX52; -.
DR   STRING; 1262929.BN691_02101; -.
DR   Proteomes; UP000018359; Unassembled WGS sequence.
DR   GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1560; -; 1.
DR   Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR   InterPro; IPR040577; Gln-synt_C.
DR   InterPro; IPR008147; Gln_synt_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR022147; GSIII_N.
DR   PANTHER; PTHR42974; GLUTAMINE SYNTHETASE; 1.
DR   PANTHER; PTHR42974:SF1; TYPE-3 GLUTAMINE SYNTHETASE; 1.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   Pfam; PF18318; Gln-synt_C-ter; 1.
DR   Pfam; PF12437; GSIII_N; 1.
DR   SMART; SM01230; Gln-synt_C; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
DR   PROSITE; PS51986; GS_BETA_GRASP; 1.
DR   PROSITE; PS51987; GS_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000313|EMBL:CDB05273.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018359}.
FT   DOMAIN          85..174
FT                   /note="GS beta-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS51986"
FT   DOMAIN          179..615
FT                   /note="GS catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51987"
SQ   SEQUENCE   729 AA;  82712 MW;  38188CA0F3008B1E CRC64;
     MANLRFEVVA EAFNKKPVEV ITPIERPSEF FGKNVFNRAK MYKYLPREVY EKLVDVIDNG
     ARLDRSIADA VAKGMKQWAD ENGVTHYTHW FQPLTEGTAE KHDAFIEHDG KGGMIEEFSG
     KLLVQQEPDA SSFPNGGIRN TFEARGYSAW DPTSPVFIID DTLCIPTIFI SYTGEALDYK
     APLLRSLHAV NEAATAVCHY FYPEVKKVIS NLGWEQEYFL VDEGLYSARP DLMLTGRTLM
     GHDSAKNQQM DDHYFGAIPE RVQAFMKDLE IQALELGIPC KTRHNEVAPN QFELAPIFEE
     TNIAIDHNML LMSLMKKVAR RHGFRVLLHE KPFAGINGSG KHENWSLSTD TGVLLHGPGK
     TPEDNLRFIV FIVETLMAVY KHNGLLKASI MSATNAHRLG AHEAPPAIVS SFLGRQLTEI
     LSHIAASDKD ELFDVAGKLG LKLDIPEIPE LLIDNTDRNR TSPFAFTGNR FEFRAVGSEA
     NCASAMIVLN TAVAEALQSF KQRVDALIEN GSDKVSAILD IVREDIHTCA PVHFEGNGYS
     EEWVEEAKRR GLDCETSCPK VFERYLDEDS IRMFESQNVM TRKELEARNE VKWETYTKKI
     QIEARVFGDL SMNHIIPVCT HYQSRLAKNV QSMYDIFPKE TADNLTSRNK KIIEEIAERT
     QIIENGVEEL VEARKVANRI EDEHLKAIAY HDTVAPKMDE IRYHIDKLEL IVADELWTLP
     KYRELLFVR
//