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Database: UniProt
Entry: R6F124_9FIRM
LinkDB: R6F124_9FIRM
Original site: R6F124_9FIRM 
ID   R6F124_9FIRM            Unreviewed;       569 AA.
AC   R6F124;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE            Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN   ORFNames=BN497_00366 {ECO:0000313|EMBL:CDB02736.1};
OS   Firmicutes bacterium CAG:145.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263005 {ECO:0000313|EMBL:CDB02736.1, ECO:0000313|Proteomes:UP000018044};
RN   [1] {ECO:0000313|EMBL:CDB02736.1, ECO:0000313|Proteomes:UP000018044}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:145 {ECO:0000313|Proteomes:UP000018044};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC       Ala-charged tRNA and directs the elongation of stalled nascent chains
CC       on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC       extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC       May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC       ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00844}.
CC   -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC       Rule:MF_00844}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB02736.1}.
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DR   EMBL; CBCX010000068; CDB02736.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6F124; -.
DR   STRING; 1263005.BN497_00366; -.
DR   Proteomes; UP000018044; Unassembled WGS sequence.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR   HAMAP; MF_00844_B; RqcH_B; 1.
DR   InterPro; IPR008532; NFACT_RNA-bd.
DR   InterPro; IPR043682; RqcH_bacterial.
DR   PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   PANTHER; PTHR15239:SF6; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR   Pfam; PF05670; NFACT-R_1; 1.
DR   Pfam; PF18297; NFACT-R_2; 1.
DR   Pfam; PF05833; NFACT_N; 1.
PE   3: Inferred from homology;
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000018044};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW   Rule:MF_00844};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW   Rule:MF_00844}.
FT   DOMAIN          445..545
FT                   /note="NFACT RNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF05670"
SQ   SEQUENCE   569 AA;  64011 MW;  BF557709CD3D6617 CRC64;
     MAFDGIVTMA AAKEMRPVII SGKIDKVYQP EADELVFNIH TKRGNVKLYA SVNPAAARIH
     FIENSLQNPP APLPFCMLLR KHIQGARVTD VAQVGSERII EISLETLNEL GFTVSKKLIF
     EIMGKHSNIV LLDISSGKII DCIKHVSIDV NRVRQLLPGI IYKYPPAQDK IPFKELLPEG
     SPSVFLPPEA KAIQRTVGGV SPSFAQEMAA SEDPLSFLRS AARIIEEGRF CPVVYSDDKG
     SPKEFHIIPL SEYEDVCQKK EFDSLSLCLE YYYAHKQSSN KLHQKASDLE RSVSSQLDKL
     YLKEQRLRED LLKAENSESL RLYGELLTAN IHQVRPGDKS TSVINYYDGS TVTIPLDPRL
     SPSKNAQQYF KKYGKAKTAV KEKQLQLRTN ESDIKYLDSV MSYLKNASDV SEIEALRREL
     EETGYLRKRK IPGGFKEKKI SSKPYRYILP GGCEVLVGRN NRENDILTFK TASSRDIWMH
     TKDIPGSHVI VKTSCEEISD EDLYTAASIA AYHSKGRESE NVPVDYVRVK YVKKPAGAKP
     GMVIFTNNKT VWVDPKLPKA EEEQGSDHL
//
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