ID R6GTV9_9FIRM Unreviewed; 715 AA.
AC R6GTV9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=(P)ppGpp synthetase I SpoT/RelA {ECO:0000313|EMBL:CDB28888.1};
GN ORFNames=BN721_01238 {ECO:0000313|EMBL:CDB28888.1};
OS Firmicutes bacterium CAG:582.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1262997 {ECO:0000313|EMBL:CDB28888.1, ECO:0000313|Proteomes:UP000018398};
RN [1] {ECO:0000313|EMBL:CDB28888.1, ECO:0000313|Proteomes:UP000018398}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:582 {ECO:0000313|Proteomes:UP000018398};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB28888.1}.
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DR EMBL; CBDJ010000047; CDB28888.1; -; Genomic_DNA.
DR AlphaFoldDB; R6GTV9; -.
DR STRING; 1262997.BN721_01238; -.
DR UniPathway; UPA00908; UER00884.
DR Proteomes; UP000018398; Unassembled WGS sequence.
DR GO; GO:0015970; P:guanosine tetraphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018398}.
FT DOMAIN 387..448
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 715 AA; 81931 MW; 3C777D6C5B7D8808 CRC64;
MEKLYEELLK KCEENGYSDE EIENIKRAYE FAYKCHKGKM RKNNEEFITH PLNVALICAS
LNVDSTTIIS ALVHETIDNG PSSLEEIESL FGEEVMHIVS SLMKVNRLKL TDESESTSLY
LRKVLVALSE DVRVLIIKLA GRVHNMRTIY PFSKEKQRLK AIETQNVLIP IAHRLGINQL
KTELEDICFR VLKNEDYKSV EESLPASREK LNEILEETKE TIIEELKQNN ISFEIKGRVK
SNSSIYNKLS KGKKMSEIYD IIGLRIICEE ESECYLIIGL IHSLYRPIPK RFKDYISMPK
GNSYQSLHTG VFGPEGFPVE VQVRTKEMNE IAEHGVASHW SYKEHSKQIQ NVMEQKLQMF
RNIIEANSND ITDDDTFAQN MSELLSTSIY VYTPKGDVVE LPEGSCPVDF AYRIHSRVGD
TTIGAIVNDT IVPLDYHLQD NDIVKIMTNA QSEPNKDWLN FVKTTQAKAK IKAFFSKKDR
EEYIERGRNL LEKELKRQHI TVSSALDDEH INKLVSDLKV TNFDEVLLNI GALRYTPSYI
VDLMYNDKKN VQDVLLDKVM NSSTLPKVNH KNDIVVSGCD DILVNLASCC KPVFGDEIIG
YITKGQGITV HKKDCVNVKD LNERLIDVYW NENRNDENKY YISKITVYTN GVQNNILDIV
TKSTVRGINI NSINEVNKGG KVCYDLILKV KNKADLDNFI EDLRTLKFVT SISRY
//
