ID R6H7A6_9ACTN Unreviewed; 365 AA.
AC R6H7A6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:CDB33578.1};
GN ORFNames=BN534_00104 {ECO:0000313|EMBL:CDB33578.1};
OS Eggerthella sp. CAG:209.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=1262875 {ECO:0000313|EMBL:CDB33578.1, ECO:0000313|Proteomes:UP000018042};
RN [1] {ECO:0000313|EMBL:CDB33578.1, ECO:0000313|Proteomes:UP000018042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:209 {ECO:0000313|Proteomes:UP000018042};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB33578.1}.
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DR EMBL; CBDM010000157; CDB33578.1; -; Genomic_DNA.
DR AlphaFoldDB; R6H7A6; -.
DR Proteomes; UP000018042; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Reference proteome {ECO:0000313|Proteomes:UP000018042}.
FT DOMAIN 5..357
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 365 AA; 38889 MW; 9B0AE7BE27949510 CRC64;
MAKHTVTLIP GDGIGLETTA AMRRVVEACG VDIEWEIAEA GAHMMDSCGT PLPEATIGAV
RRNKVAIKGP ITTPVGTGFR SVNVALRKTL NLNVCLRPVL SIPGAGGRYQ DVDLVIVREN
SEDLYAGIEF EEGSKEAAEL IEFCKQHDAG TIRSDSGISI KPISVTASQN IVRYAFDYAV
KHGRKKVTAA HKANIMKHSD GLFLRTAREV AADYEGSIEF NDNIIDAFCM NLVMDPSQFD
VIVFPNLYGD IASDLCAGLV GGLGIAPGAN IGPDYAIFEA VHGSAPDIAG KNICNPTAEI
LSAAMMLDHL GELEAAQRIR DAVRKVYAEG EVLTADIRKA TGSDKPAASC SQFTDELISA
LTRLA
//
