ID R6HAV1_9ACTN Unreviewed; 589 AA.
AC R6HAV1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Cell division protein FtsI/penicillin-binding protein 2 {ECO:0000313|EMBL:CDB33920.1};
GN ORFNames=BN534_01626 {ECO:0000313|EMBL:CDB33920.1};
OS Eggerthella sp. CAG:209.
OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC Eggerthella.
OX NCBI_TaxID=1262875 {ECO:0000313|EMBL:CDB33920.1, ECO:0000313|Proteomes:UP000018042};
RN [1] {ECO:0000313|EMBL:CDB33920.1, ECO:0000313|Proteomes:UP000018042}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:209 {ECO:0000313|Proteomes:UP000018042};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB33920.1}.
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DR EMBL; CBDM010000192; CDB33920.1; -; Genomic_DNA.
DR AlphaFoldDB; R6HAV1; -.
DR Proteomes; UP000018042; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.330; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:CDB33920.1};
KW Cell division {ECO:0000313|EMBL:CDB33920.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018042};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 46..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 88..234
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 278..577
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 64038 MW; F90734FBDAC96643 CRC64;
MDDRSSSRRP QRQGSAPRSQ RQRPPVRPQR GGRGMHMDMD VLNGRLAIFF VAFCVFALIL
AIRLFGLMVI DAQANLNRDS SREVTVDVQP RRGTIYDRNG TILATTVDAY NVFCHPHMVS
SDKVDQLAQA LADAFGGEVQ DYRNKITTDS NFAYLYKGAD EDGMKKIKDL GIEGVDFEKT
TKRVYPCGAT ASQIIGILNS DGKAITGLEL YYDDILGGTA GHKTTEYSKE GVPVPGSEKV
TAEVVNGQDI VLSIDIDMQQ KLEESLALRV EEVQGKGGSA ILMDSATGEI YACSSSPTFD
ITDLSEVKEG ATNLSGISSA YEPGSIMKPL TMLAALLDGK VTLDSTYYCP AALKVDDYTI
TDSHERPSED MSVSTIIAES SNVGISLVAK DLTFTRLYEY IQQFQLCDKT GVDYPGEASG
TIAPKNEWST VQGYNISFGQ GLTTTPIEMV RFYGALANDG VACTPHFLTD VPSESERRSY
ETAQITDNAG AISDLESMMQ QTVERGTATD AQIKGYRVVG KTGTAEIASD TGGYKKGMYN
ISFIGYLPDT STNLVCFVGA TDVPGERKTV GTFRDIMAFA IDRYNITQN
//
