ID   R6HL27_9ACTN            Unreviewed;       244 AA.
AC   R6HL27;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase {ECO:0000313|EMBL:CDB33991.1};
GN   ORFNames=BN534_00154 {ECO:0000313|EMBL:CDB33991.1};
OS   Eggerthella sp. CAG:209.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Eggerthella.
OX   NCBI_TaxID=1262875 {ECO:0000313|EMBL:CDB33991.1, ECO:0000313|Proteomes:UP000018042};
RN   [1] {ECO:0000313|EMBL:CDB33991.1, ECO:0000313|Proteomes:UP000018042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:209 {ECO:0000313|Proteomes:UP000018042};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB33991.1}.
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DR   EMBL; CBDM010000201; CDB33991.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6HL27; -.
DR   Proteomes; UP000018042; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   CDD; cd02009; TPP_SHCHC_synthase; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR42916; 2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE; 1.
DR   PANTHER; PTHR42916:SF1; PROTEIN PHYLLO, CHLOROPLASTIC; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018042};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          86..229
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   244 AA;  26595 MW;  5D5FB18F11D6CA99 CRC64;
     MVALLEAGTV PDPEESMAYA PLPQNVHEWG LIDRARTERI LATDFAADSQ FEGSYLRAML
     EEIPAESLLF TANSMSVRAL DAFYVSQAKH LTVLANRGLN GIDGTVSTAL GAAQSFKQTV
     MVTGDLTLLH DLNSLALQGE MLLRERQGSP RPSIVIVLLN NNGGAIFDML PQKSDESYFE
     RLFLTPQKVD FAAAAGAFGV PTATVHTVAE FKQAFSGFLG EQGISLIEVP LPLTGVRERY
     DQYW
//