ID R6HWD9_9FIRM Unreviewed; 492 AA.
AC R6HWD9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Glycosyl hydrolase family 43 {ECO:0000313|EMBL:CDB41360.1};
GN ORFNames=BN517_01433 {ECO:0000313|EMBL:CDB41360.1};
OS Ruminococcus sp. CAG:177.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262952 {ECO:0000313|EMBL:CDB41360.1, ECO:0000313|Proteomes:UP000018315};
RN [1] {ECO:0000313|EMBL:CDB41360.1, ECO:0000313|Proteomes:UP000018315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:177 {ECO:0000313|Proteomes:UP000018315};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB41360.1}.
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DR EMBL; CBDQ010000032; CDB41360.1; -; Genomic_DNA.
DR AlphaFoldDB; R6HWD9; -.
DR STRING; 1262952.BN517_01433; -.
DR Proteomes; UP000018315; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651};
KW Reference proteome {ECO:0000313|Proteomes:UP000018315};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651}.
FT SITE 147
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 492 AA; 55107 MW; 89D17DE77833854C CRC64;
MKKYAYNPIL PLDKYIPDGE PHVFDGRVYL FGSHDREGGN TFCELDYEFF SAPIDNLSNW
SSNGINYCSK QDALYTNERP YMYAPDVVRG NDGKYYLYYC LAGEKGSGGY NGPVSVAVCD
KPDGKYEYLG YVKNRDGSPF DKFVCFDPAV INDGGVIRLY YGTSMPKGMC LPRFARKAAS
PIFEKIYGKS KAEITSEPGI WGANTVTLCD DMQTVKTAAV RIIPEKTKGT SFENHAFFEG
SSIRKINGMY YFIYSSQKNH ELCYAVSKEP DRNFEYGGTI VSTGDVGFDG RKEKDRLNVT
GTTHGSIEFI NGRWYVFYHR LTHASDYSRQ ACAEPIKINE DSSICQVEIS SSGLEAKPLS
ASGIYPAVIA CNITNGRMPH ISNRRYNGNI PKITDCRGER YIADIDRRTA VCYKWFDFVS
DTGEIILDID SHADGKIVVF ANRIPIASAA ITPCGRSKII MQYKVHDANS QTLSINFSGK
GTFDLYTIEF KE
//
