ID R6I312_9FIRM Unreviewed; 768 AA.
AC R6I312;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Beta-galactosidase GHF2 {ECO:0000313|EMBL:CDB43695.1};
GN ORFNames=BN556_01156 {ECO:0000313|EMBL:CDB43695.1};
OS Firmicutes bacterium CAG:240.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263013 {ECO:0000313|EMBL:CDB43695.1, ECO:0000313|Proteomes:UP000018051};
RN [1] {ECO:0000313|EMBL:CDB43695.1, ECO:0000313|Proteomes:UP000018051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:240 {ECO:0000313|Proteomes:UP000018051};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB43695.1}.
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DR EMBL; CBDR010000129; CDB43695.1; -; Genomic_DNA.
DR AlphaFoldDB; R6I312; -.
DR Proteomes; UP000018051; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR42732:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000018051}.
FT DOMAIN 34..145
FT /note="Glycosyl hydrolases family 2 sugar binding"
FT /evidence="ECO:0000259|Pfam:PF02837"
FT DOMAIN 155..237
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 239..439
FT /note="Glycoside hydrolase family 2 catalytic"
FT /evidence="ECO:0000259|Pfam:PF02836"
SQ SEQUENCE 768 AA; 86056 MW; 703CA73E51347D03 CRC64;
MDIAFNNGWL FTEDYDAGFD KASSVRLPHT AREIPYNYID CRDYQMVCGY RKSFTAPSEW
QGKRIILRFD GAAHEATVFC NGTRVGYHAC GYTAFSVDIT DSVNFGGENT VDVRLDTRES
LNIPPFGFVI DYLCYGGLYR EVTLEVKDPE YIKEVLIENT GLHELRVRIE SECESVATDI
VDGSGKVIAS ACGKAFELSV PNAQLWSLDS PALHTARVRA MRGGEVVDEK SLRFGFRTVR
FENDGFYLNG QRIKLRGLNR HQSYAYVGYA MPKSVQELDA EILKNELGVN AVRTSHYPQS
QHFISRCDEL GLLVFTEIPG WQHIGDEDWK RQAVKNTDEM VRQYMHHPSI MLWGVRINES
QDCDELYRKT NAVAHTLDSG RQTSGVRYLE KSHLLEDVYA YNDFSHTGDN AGLKAKKNVT
SKKHRPYFVS ECNGHMFPTK PFDDERHRLS HALRHAKVLD AMYAADDICG IFPWCMFDYN
THQDFGSGDG ICYHGVMDMF RNPKLAAAVY ASQSDNVPCC VVSSSMDIGE HPAGDIGKVY
VFTNADSVKL YKDGVFVREF FPGKDEYPAL PHPPVIIDDF IGELLITQEG FDEKTAATVK
ECLLAVAKSG PSALPPKILA KFARLMLTKG FKFSDGVELY GKYVGNWGGE ATKWRFDAIR
DGEVIKRVTR SPGQKVHLEV RPSKTELSEG NTYDAAEVRI RALDEYGSLA PYWQEPVVLK
CSGALELIGP EIISLKGGSG GCYVKTVGKA GLGRLSVNDI EIEFNINM
//
