ID R6I6M4_9FIRM Unreviewed; 805 AA.
AC R6I6M4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN533_02190 {ECO:0000313|EMBL:CDB44970.1};
OS Phascolarctobacterium faecium.
OC Bacteria; Bacillota; Negativicutes; Acidaminococcales; Acidaminococcaceae;
OC Phascolarctobacterium.
OX NCBI_TaxID=33025 {ECO:0000313|EMBL:CDB44970.1, ECO:0000313|Proteomes:UP000014944};
RN [1] {ECO:0000313|EMBL:CDB44970.1, ECO:0000313|Proteomes:UP000014944}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:207 {ECO:0000313|Proteomes:UP000014944};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB44970.1}.
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DR EMBL; CBDS010000005; CDB44970.1; -; Genomic_DNA.
DR AlphaFoldDB; R6I6M4; -.
DR STRING; 1262914.BN533_02190; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_114_15_9; -.
DR Proteomes; UP000014944; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000014944};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 436..660
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 684..805
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 736
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 805 AA; 91963 MW; 2BFE53D27C4FD72F CRC64;
MEKKLLLEQF NKDFAAMQRG MMMQFDKLPL PVYVLRVEAD ASGLPQDFIF VYANSACASF
LGIDGKNYLL GMSFSDIWGD NGAKWLNIYT KTALEGLTQN IEDYNENLKK YLSVDCYQPM
YGYCGCFMRD VTQRRDMERQ LYEEKERYRV AMESSIDLLF EYDIRLQVMH SWSNIASENS
QEKTRRSYIP DYLSVVIKEN LVDPSDREAW LGLLRGERSE EALEIRMRRY IDEQVDNKWY
LVQATTVYEQ GLPVRVVGTM RDIDAWKRMQ QEKQLVESLN YEINHVLGDI YYAVVHFDLD
AGTYHFVELT GQKCVDYPYN GTCEEFLAYT RDVVPREDWH KFRQRFNLRE MRRVLTKTGD
KLEMELRRKN GGVYKWISLM VSYLPDYSGS KKQQAVLVAR FIDDERRREM EQQQELKEAL
VAAHTANEAK SAFLSQMSHD IRTPMNAIIG MTTIARQNIE NKVKTLDCLN KIGSSSAHLL
ELINSILSMS KIESGKVILT DDELSLPQLL EDVLNIIRPM AGKKMQNLRL ELEELKHAEV
LTDSTHLKQI LLNVLGNAVK YTPEGGEIVL GLQELSAVIP QRSQYVFTVS DNGPGLSEEL
LPKIFDMFER GEDSRTSKIE GTGLGLAICK NLTNLMAGTI EAANRPEGGA KFTLTLPLRW
LGDDAVKPLP AVKPAGRSDF SGHRVLIVED NDLNMEIALE FLQSLGVVCE GAENGRRAVE
MFNASAPGHY EMILMDVRMP VMNGYEATRE IRRLAREDAR QIPIVAMTAD AFSSDIKMAL
NAGMNEHLSK PVSIERLQEV LGQWL
//
