ID   R6I8T9_9ACTN            Unreviewed;       719 AA.
AC   R6I8T9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Superfamily I DNA helicase {ECO:0000313|EMBL:CDB34452.1};
GN   ORFNames=BN534_00543 {ECO:0000313|EMBL:CDB34452.1};
OS   Eggerthella sp. CAG:209.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Eggerthella.
OX   NCBI_TaxID=1262875 {ECO:0000313|EMBL:CDB34452.1, ECO:0000313|Proteomes:UP000018042};
RN   [1] {ECO:0000313|EMBL:CDB34452.1, ECO:0000313|Proteomes:UP000018042}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:209 {ECO:0000313|Proteomes:UP000018042};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB34452.1}.
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DR   EMBL; CBDM010000282; CDB34452.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6I8T9; -.
DR   Proteomes; UP000018042; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   PANTHER; PTHR11070:SF17; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018042}.
FT   DOMAIN          227..565
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          39..66
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         248..255
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   719 AA;  80736 MW;  80506ECF51E6ADCA CRC64;
     MTGTELHNIA AASQNTENSA DAVFQEEQNH LTSTYEAIEK IERNVLENMR KTAQEAEEDK
     RNMADELASN FASDGEKQET YIEYANMNSV IDSYNRTQRA NAEKLTAVRI LKPQPYFAKV
     VLQYKPGAAP KELYIGNAGL SDDSYRRLIV DWRSPVAEVY YNQADGKTSY EANGRTINVD
     LKLRRQFDIT GSKLNACFDT TIAIQDELLL ASLSRQRTSQ MQAITTTIQK EQNVVIRHKD
     VPALLVNGIA GSGKTSVLLQ RIAYLFYQKR ESLDPRQVFL ITPNPVFRDY IDNVLPDMGE
     RNPNILTWNE FAEGTIPPGR DFKRFDTSFE TLQLIDEAVD SLELQDKDFR DIKSQGTVLI
     NAQQIAKAAA KFKNAPAGPH RITLIREELE TRLQSRLGQM ANNTAAQDVV SELSYNDQLS
     IFGEPITMDT EENAKAFTLK FLTQQYESAF EAVKNDYWLR IDRIGKRIAG IEDLSFLEWL
     YLKIRITGMS NPDTKYVMID EVQDYTTAQL AILSRYFRRA NFLLLGDENQ AIKPGTASFD
     EIRHVFEATR GEVSECHLMT SYRSTPAITE LFAKLAITAD GMQISSVQRA DTEPEFHECA
     TESEYIQDLV QAARESKELK GTTAFVALNT EAATRTAQLL GDDSPALIGE GDTLPNSGSI
     LLALPLAKGL EFDHVVIVNA SKEDFPDNDL SRRRLYTAIS RATSTVSVFS NGELSPLLK
//