ID R6IDX4_9FIRM Unreviewed; 830 AA.
AC R6IDX4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Putative translation elongation factor G {ECO:0000313|EMBL:CDB43561.1};
GN ORFNames=BN556_01051 {ECO:0000313|EMBL:CDB43561.1};
OS Firmicutes bacterium CAG:240.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263013 {ECO:0000313|EMBL:CDB43561.1, ECO:0000313|Proteomes:UP000018051};
RN [1] {ECO:0000313|EMBL:CDB43561.1, ECO:0000313|Proteomes:UP000018051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:240 {ECO:0000313|Proteomes:UP000018051};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB43561.1}.
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DR EMBL; CBDR010000111; CDB43561.1; -; Genomic_DNA.
DR AlphaFoldDB; R6IDX4; -.
DR Proteomes; UP000018051; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd10912; PIN_YacP-like; 1.
DR CDD; cd03711; Tet_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR010298; YacP-like.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF05991; NYN_YacP; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Elongation factor {ECO:0000313|EMBL:CDB43561.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:CDB43561.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018051}.
FT DOMAIN 1..226
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 830 AA; 92766 MW; 94FDA7F7A06CD02E CRC64;
MKKLVLGVLA HVDAGKTTLS EALLYTCGSI RKLGRVDHRN TALDTHKIER ERGITVFSKQ
AQLHTGGMEL CLLDTPGHAD LTAETERTLD VIDYALLVIS GTDGVQAHTE TLWRLLDRHN
VPTIIFATKM DLTGSDRQRI LSDLRERLSE GCFDLSDNSQ ETREGIAMCD EELFEKFASG
QDIADGDISR LILERKLFPV LYGSGLKLEG VQELVEFIEK CAVSPEYPEQ FGARVYKIMR
DARDRRLSCM KITGGALHNR DSVNGQTVTE LRVYSGANYE TVQEARAGSI VAVQGLDDTY
AGQGLGFEGD GMQPETEAVM SYSIGLPEGT DALVAYRQLK QLEDEDPQLK IEWSERLREI
SVKIMGKVQT EVLTELIRER FALDVSIASG GIAYKETIAE PVHGVGHFEP LRHYAEVHLL
IEPAERGSGL SFESRCPLDE LDRNWQSLIM TNLAEKTHLG VLTGSPLTDV RISLIAGRAH
VKHTEGGDFR EAVYRAVRQG LMKAKSVLLE PWYDFRIEVP PEQIGRAISD VRAMSGKFDT
EGSSIITGIA PVSEMNGYAE TLASYTSGKG RIVCRAAGYY PCHNEKQVIE SIGYDPEADV
DNTPDSVFCS HGAGTVVKWN ETEKYMHLNP DLGGEKAPEE FSRPRYFSID DKELEAIMER
EFGPVRRRMY TKAQTVIEAP EYSVAPSKRE YVIVDGYNFI FGTPEYKELA AASLSLARER
LSDVLRSYRA MRDCELVLVF DGYRVAGNTG ERETHGIRTV YTKENETADM YIERLANDIG
KNYSVKVVTN DSLIRLSAMR SGVLRMSVKE FSDELDGVMK RIMEYIDGKR
//
