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Database: UniProt
Entry: R6IRU1_9PROT
LinkDB: R6IRU1_9PROT
Original site: R6IRU1_9PROT 
ID   R6IRU1_9PROT            Unreviewed;       657 AA.
AC   R6IRU1;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   05-DEC-2018, entry version 27.
DE   RecName: Full=Transketolase {ECO:0000256|RuleBase:RU004996};
DE            EC=2.2.1.1 {ECO:0000256|RuleBase:RU004996};
GN   ORFNames=BN570_00050 {ECO:0000313|EMBL:CDB40727.1};
OS   Azospirillum sp. CAG:260.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodospirillales;
OC   Rhodospirillaceae; Azospirillum; environmental samples.
OX   NCBI_TaxID=1262706 {ECO:0000313|EMBL:CDB40727.1};
RN   [1] {ECO:0000313|EMBL:CDB40727.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J.,
RA   Sunagawa S., Plichta D., Gautier L., Le Chatelier E., Peletier E.,
RA   Bonde I., Nielsen T., Manichanh C., Arumugam M., Batto J.,
RA   Santos M.B.Q.D., Blom N., Borruel N., Burgdorf K.S., Boumezbeur F.,
RA   Casellas F., Dore J., Guarner F., Hansen T., Hildebrand F., Kaas R.S.,
RA   Kennedy S., Kristiansen K., Kultima J.R., Leonard P., Levenez F.,
RA   Lund O., Moumen B., Le Paslier D., Pons N., Pedersen O., Prifti E.,
RA   Qin J., Raes J., Tap J., Tims S., Ussery D.W., Yamada T.,
RA   MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P., Wang J.,
RA   Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units
RT   of genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the transfer of a two-carbon ketol group from
CC       a ketose donor to an aldose acceptor, via a covalent intermediate
CC       with the cofactor thiamine pyrophosphate.
CC       {ECO:0000256|RuleBase:RU004996}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-
CC         phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-
CC         phosphate; Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483,
CC         ChEBI:CHEBI:57737, ChEBI:CHEBI:58273, ChEBI:CHEBI:59776;
CC         EC=2.2.1.1; Evidence={ECO:0000256|RuleBase:RU004996};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU004996}.
CC   -!- SIMILARITY: Belongs to the transketolase family.
CC       {ECO:0000256|RuleBase:RU004996, ECO:0000256|SAAS:SAAS00570687}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CDB40727.1}.
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DR   EMBL; CBDP010000097; CDB40727.1; -; Genomic_DNA.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR005478; Transketolase_bac-like.
DR   InterPro; IPR020826; Transketolase_BS.
DR   InterPro; IPR033248; Transketolase_C.
DR   InterPro; IPR033247; Transketolase_fam.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR43522; PTHR43522; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   SUPFAM; SSF52922; SSF52922; 1.
DR   TIGRFAMs; TIGR00232; tktlase_bact; 1.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
DR   PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU004996};
KW   Magnesium {ECO:0000256|RuleBase:RU004996,
KW   ECO:0000256|SAAS:SAAS00086467};
KW   Metal-binding {ECO:0000256|RuleBase:RU004996,
KW   ECO:0000256|SAAS:SAAS00086515};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU004996,
KW   ECO:0000256|SAAS:SAAS00086495};
KW   Transferase {ECO:0000256|RuleBase:RU004996,
KW   ECO:0000256|SAAS:SAAS00086511}.
FT   DOMAIN       16     36       TRANSKETOLASE_1. {ECO:0000259|PROSITE:
FT                                PS00801}.
SQ   SEQUENCE   657 AA;  71542 MW;  510A0E1EC04B8AB4 CRC64;
     MSSGEKQLAA MANAIRFLSA DAIEKSKSGH PGMPLGMADV AAVLFSKFIK LNPEAPRWFD
     RDRFVLSAGH GSMLMYSLLY LMGYEDITID DIMNFRQLGA KTAGHPEYGH LAGIDMTTGP
     LGQGISSAVG MALAERMINA KFGDDLCSHY TYVINGDGCL MEGISEEAVS LAGHLGLNKL
     IVLWDNNNIT IDGTVDKANS TDQIKRFQAV GWNTIEIDGH DYGEIEKAIA KAQKSDKPTL
     IACKTKIGFG APTKCGTSKC HGSPLGEEEI AAMRKALNWN YDPFEVPEDI LAAWRSAARR
     NADVYAKWQE KAHAAGKEFD DFINDRLPAD WDKHLKALEE KAIAEQTKVA TRKASQLCLE
     QIVPYVPQIV GGSADLAASN LTFVDGMKSV AKNDYKGNNV MYGIREHAMG AIMNGLALHG
     GAIPYGGTFF VFSDYMRPAM RLAALMGIRV IYVLTHDSIG VGEDGPTHQP IEHLASYRAM
     PNIYTMRPCD VVETAECWRI AIESESTPSI LALSRQNLPL LRKSAELNLS ARGGYIIAGD
     KDKRQATLIA TGSEVSLAVE ARNELAEEGI EVAVVSMPCT ELFDRQDISY QEEVLGTAPR
     IAIEAASKFG WERYVGLNGD IIGMDGFGAS GPAAELYNYF GITKEEIIDS VKNLLKE
//
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