ID   R6K4V6_9FIRM            Unreviewed;      1411 AA.
AC   R6K4V6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=CoA-substrate-specific enzyme activase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN564_02086 {ECO:0000313|EMBL:CDB68450.1};
OS   Eubacterium sp. CAG:252.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262887 {ECO:0000313|EMBL:CDB68450.1, ECO:0000313|Proteomes:UP000017970};
RN   [1] {ECO:0000313|EMBL:CDB68450.1, ECO:0000313|Proteomes:UP000017970}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:252 {ECO:0000313|Proteomes:UP000017970};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB68450.1}.
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DR   EMBL; CBEA010000105; CDB68450.1; -; Genomic_DNA.
DR   Proteomes; UP000017970; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014}.
FT   DOMAIN          8..220
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          322..576
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          672..888
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1411 AA;  155744 MW;  C9955F6DB12880B7 CRC64;
     MTMNKYRLGI DIGSTTVKIA ILDDNNNILF SDYERHFANI QETLQGLLEK AVSQLGQFEV
     YPVITGSGGL TLAKHLEVPF TQEVVAVSTA LQDYAPQCDV AIELGGEDAK IIYFTNGIDQ
     RMNGICAGGT GSFIDQMATL LQTDASGLNE YAKNYKSIYP IAARCGVFAK SDIQPLINEG
     ATKEDLSASI FQAVVNQTIS GLACGKPIRG NVAFLGGPLH FLSELKQAFV RTLSLTPEQT
     IAPEHSHLFA AVGSAMNYSK DVCVNVSDII KRLSGKIKLE FEVERMEPLF ADQLAYNDFI
     KRHNAHHVKT ADIASYEGNC YLGIDAGSTT TKVALVDEDG NLLYSFYSSN NGSPLATTIK
     AIKEIYSQLP PKAKIVQACS TGYGEALIKS ALMLDEGEVE TVSHFYAAAF FDPDVDCIID
     IGGQDMKCIK IKNQTVDSVQ LNEACSSGCG SFIETFAKSL NYSVQDFAKA ALFAAHPIDL
     GTRCTVFMNS KVKQAQKEGA EVSDISAGLA YSVIKNALYK VIKIADPGDL GKHIVVQGGT
     FYNDAVLRSF EKITGVDAIR PDIAGIMGAF GAALIARERY DGISDSSMLS IDKINSLTYE
     TTLTRCKGCT NSCHLTINKF SGGRSFITGN RCERGLGKER NKEKAPNLFD YKFHRLFDYE
     PLSADLAVRG VVGIPRVLNM YENYPFWFTF FTKLGYKVVL SPQSTRKIYE LGIESIPSES
     ECYPAKLAHG HISWLIKKGV KFIFYPCVPY EHKEIDGTNN HYNCPIVTSY AENIKNNVEE
     IKSENIDFRN PFLSFESEDI LAKRLKEEFP DIPAGEIKAA VSDAWKELMQ SREDMHKKGE
     EVIQYLKDNN KRGIVLAGRP YHIDPEINHG IPELINSYGI AVLTEDSVAH LGNVERPLVV
     MDQWMYHSRL YAAASFVKTQ DNLDLIQLNS FGCGLDAVTT DAVNDILTKS GKIYTVLKID
     EVNNLGAARI RIRSLIAALK VRDKKNYKHT LVSSAYNRVE FTPEMRKNYT ILCPQMSPIH
     FDLLEPALNS CGYNFEVLDN DNKSSVDMGL KYVNNDACYP SLMVVGQIMN AVLSGKYDLS
     KTAIIITQTG GGCRASNYIG FIRRALEKAN LEYIPVISLS AQGLETNSGF KYDLKMLKKA
     MMAIEYGDVF MNVVYRTRPY EKVAGSVNEL HEHWKEICIK QLTADKVRMK DFNNNLRAIV
     KDFDNIELLD IKKPRVGVVG EILVKFLPAA NNYLVDLLEA EGAEAVVPDL LGFLLYCAEN
     ANFKHKYLGT SGKSAFINNS VIKLLEWFRK AGNKALAESK RFDAPSSIKE TAALAKDLVS
     LGNQTGEGWL LTGEMIELIH HGAGNIVCCQ PFACLPNHIV GKGVIKELRA AFPEANIIAV
     DYDPGASEVN QLNRIKLMLA TANKNLNAAS N
//