ID   R6KRG0_9BACE            Unreviewed;       686 AA.
AC   R6KRG0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=HD/PDEase domain-containing protein {ECO:0000259|SMART:SM00471};
GN   ORFNames=BN506_00912 {ECO:0000313|EMBL:CDB73739.1};
OS   Bacteroides cellulosilyticus CAG:158.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1263038 {ECO:0000313|EMBL:CDB73739.1, ECO:0000313|Proteomes:UP000018191};
RN   [1] {ECO:0000313|EMBL:CDB73739.1, ECO:0000313|Proteomes:UP000018191}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:158 {ECO:0000313|Proteomes:UP000018191};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB73739.1}.
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DR   EMBL; CBEB010000466; CDB73739.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6KRG0; -.
DR   Proteomes; UP000018191; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018191};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        324..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        423..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          473..630
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
SQ   SEQUENCE   686 AA;  78965 MW;  80BDB981C16FE55B CRC64;
     MNKSKTKKSF SYRDLLYKAL IFIGTVAIIV YFLPRDGKFN YQFDIDKPWK YGQLMATFNF
     PIYKDDAVVK HEQDSILASF QPYYQLDKNV EKTVLSKLKT DYQSHLRDIV PSSDYMRYLE
     KRLSEIYKAG ILSTEERSKL QKDSTAVIMV IDDKLANQRG TEQLFSVKDA YAYLLTADTA
     HYSPYILRQC SLNEYLYPNL TYDEQRTETA KKEALDNYAW ANGVVQSGQK IIDRGEIVDK
     ETYNILESLR KESIQRSESI GQKRLILTGQ ILFVSIFMLC FMLYLDLFRK DYYERKGSLS
     LLFTLIMFYC VVTALMVSNN IYNVYIIPYA MLPIIIRVFL DSRTAFLTQV VTILICSICL
     RYPHEFILLQ LAAGLVAIFS LRELSQRSQL FRTALLVILT YAALYFAFEL ITENDLSKLN
     GSMYSYFIVN GILLLFTYPL LFLLEKTFGF TSNVTLVELS NINSPLLRRL SETVPGTFQH
     SMQVANLAAE AANRIGAKSQ LVRTGALYHD IGKMENPVFF TENQSGGVNP HKNLSYEQSA
     QVIISHVTDG LKLAEKNNLP KVIKDFISTH HGKGKTKYFY ISWKNEHPDE EPNEELFTYP
     GPNPFTRETA ILMMADAVEA ASRSLPEYTE ESINNLVEKI IDSQVEEGFF KECPITFKDI
     AIVKSVFKEK LKTIYHTRIS YPELKK
//