ID   R6MKY6_9BACE            Unreviewed;       446 AA.
AC   R6MKY6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=BN659_00147 {ECO:0000313|EMBL:CDC00323.1};
OS   Bacteroides sp. CAG:443.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1262739 {ECO:0000313|EMBL:CDC00323.1, ECO:0000313|Proteomes:UP000018098};
RN   [1] {ECO:0000313|EMBL:CDC00323.1, ECO:0000313|Proteomes:UP000018098}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:443 {ECO:0000313|Proteomes:UP000018098};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC00323.1}.
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DR   EMBL; CBEN010000106; CDC00323.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6MKY6; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000018098; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        323
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        382
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   446 AA;  50910 MW;  317F90C50126260D CRC64;
     MKKEYIVYKL SECAKQACRI DNELFTKYNV KRGLRNEDGT GVLVGLTKIG NVVGYERTEN
     GLKPIPGKLF YRGYDLDDIA HALLREKRFG FEEVAYLLLS GELPDSEQLD AFKELINDNM
     PLDKKTTMNI IDLEGQNIMN ILARSVLEMY TFDPNPDDIS RDNLMRQSIE LISKFPTIIA
     YAYNIYRHSI HGRSLHIRHP HENLSIAENF LYMIKRDYTP LEARMLDLLL VLQAEHGGGN
     NSTFTVRVTS STRTDTYSSI AAGIGSLKGP LHGGANIQVV KMFHHLKEVI SDWTNVDEID
     TYLMRMLRKE AYDGSGLIYG IGHAVYTISD PRAVLLKELA SELVAEKGCE KEFAFLELLE
     QRAIECFKKV KGTKKQVCSN VDFYSGFIYE MMGLPMEIYT PLFAMARIVG WTAHRIEELN
     FEGRRIIRPA YKNVLEEVGY VPITDR
//