ID R6MV20_9BACE Unreviewed; 701 AA.
AC R6MV20;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=BN659_02391 {ECO:0000313|EMBL:CDB98056.1};
OS Bacteroides sp. CAG:443.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262739 {ECO:0000313|EMBL:CDB98056.1, ECO:0000313|Proteomes:UP000018098};
RN [1] {ECO:0000313|EMBL:CDB98056.1, ECO:0000313|Proteomes:UP000018098}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:443 {ECO:0000313|Proteomes:UP000018098};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB98056.1}.
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DR EMBL; CBEN010000043; CDB98056.1; -; Genomic_DNA.
DR AlphaFoldDB; R6MV20; -.
DR Proteomes; UP000018098; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CDB98056.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..124
FT /note="Toprim"
FT /evidence="ECO:0000259|SMART:SM00493"
FT DOMAIN 124..217
FT /note="DNA topoisomerase type IA"
FT /evidence="ECO:0000259|SMART:SM00436"
FT DOMAIN 258..535
FT /note="DNA topoisomerase type IA DNA-binding"
FT /evidence="ECO:0000259|SMART:SM00437"
FT REGION 595..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..640
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 78868 MW; 7D54022C2F2303F5 CRC64;
MIVCIAEKPS VARDIAEVLG ARNRKEGYIE GNGYQVTWTF GHLCTLKEPH EYTPAWKSWS
LSSLPMLPPR FGIKLINDPG IEKQFHIIEG LMQQADEIIN CGDAGQEGEL IQRWVMQKAG
ARCPVKRLWI SSLTEEAIRE GFANLKEQSE FQPLYEAGLS RAIGDWLLGM NATRLYTLKY
GQNRQVLSIG RVQTPTLALI VKRQQEIENF KPEPYWELKT VYRETTFNST KGKFSSKEEG
EKFLETVRNS DFTVTDVSAK KGTEAPPRLF DLTSLQVECN KKFSYSADMT LQLIQSLYEK
KVATYPRVDT TFLSDDIYPK CPNILAGLKD YAGFTAPLAG KKLLKSKKVF DNSKVTDHHA
IIPTGVQPQG LTDMEKRVFD LIARRFIAVF YPDCKFSTTT VLGEVDKVEF KATGKQILEP
GWRVIFAKEQ QEEPKEGEEE RVLPLFTVGE SGPHIPDLTE KWTQPPKPYT EATLLRAMET
AGKLVDNDEL RDALKENGIG RPSTRAAIIE TLFKRHYIRK ERKNLIATPT GVELIQLIHE
ELLKSAELTG IWEKKLREIE RRSYDAATFL AELKQMVTEI VYSVLRDNTN RRVTIMPDES
SDKGTAKAKA KKGSTSKAKA SDTENETASA KPKRTRKAST TTKEQTATAQ MQPVPTTTQA
ATGDELIGTP CPLCGKGHII KGKTAYGCSE WKNGCTFRKP F
//
