ID R6P2M3_9FIRM Unreviewed; 787 AA.
AC R6P2M3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) {ECO:0000256|ARBA:ARBA00014333};
DE AltName: Full=Cyclic oligoadenylate synthase {ECO:0000256|ARBA:ARBA00032922};
GN ORFNames=BN582_01744 {ECO:0000313|EMBL:CDC18598.1};
OS Eubacterium sp. CAG:274.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262888 {ECO:0000313|EMBL:CDC18598.1, ECO:0000313|Proteomes:UP000017904};
RN [1] {ECO:0000313|EMBL:CDC18598.1, ECO:0000313|Proteomes:UP000017904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:274 {ECO:0000313|Proteomes:UP000017904};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|ARBA:ARBA00001968};
CC -!- SIMILARITY: Belongs to the CRISPR-associated Cas10/Csm1 family.
CC {ECO:0000256|ARBA:ARBA00005700}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC18598.1}.
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DR EMBL; CBEX010000012; CDC18598.1; -; Genomic_DNA.
DR AlphaFoldDB; R6P2M3; -.
DR STRING; 1262888.BN582_01744; -.
DR Proteomes; UP000017904; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09680; Cas10_III; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR013408; Cas10/Csm1.
DR InterPro; IPR048693; Cmr2-like_C.
DR InterPro; IPR041062; Csm1_B.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR02578; cas_TM1811_Csm1; 1.
DR PANTHER; PTHR36528; CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10/CSM1 (SUBTYPE III-A); 1.
DR PANTHER; PTHR36528:SF1; CRISPR SYSTEM SINGLE-STRAND-SPECIFIC DEOXYRIBONUCLEASE CAS10_CSM1 (SUBTYPE III-A); 1.
DR Pfam; PF20824; Cmr2_hel_dom2; 1.
DR Pfam; PF18211; Csm1_B; 1.
DR Pfam; PF01966; HD; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017904}.
FT DOMAIN 513..663
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 787 AA; 90454 MW; 0972426301F0138D CRC64;
MNDRAQKLAI GCLLHDFGKL LYRYNDGRNH STSGYDYLKN IDELRDQKEI LNCVRYHHGK
LLANSNVDDN DLCYITYIAD NIASASDRKQ REDNGDGSRG YVRNIPFESI FNILNGNKEK
KVYKPDVLSS KSEINYPTGE NIIFSESFYG KIVDNIKDAI RGINYTKEYI NSLLQVMESN
LTFIPSSTDK SQYVDISLYD HSKMTAAFGL CIEQYLVENE ITNYKEELFK KTKEFYKKKV
FGLLSIDLSG IQSFIYNISD EKALKNLRAR SFYLEMLMEH CVDELIERCG LCRANVMYTG
GGHTYIFVPA TSKCKKIIEN FKIELNQWFM ENFDIGLYAA FGYVECSSEE LENKESGGYR
DLFRKVNVQQ SKQKLARYSA EDILKLNGLK TEEHGRECKV CHRSDKLVDD KCSFCIGLEA
LSDMIIDNRG DNFFTIIKGE ADTKSVPMPF GCKMKAYKAD ELKNQMNNSE QYIRSYAKNR
DYTGYKISKN LWVGDYTAEK TFGDLVAKSD GIKRLGVIRA DIDNLGQAFV SGFGENEICI
TRTAVFSRKL SEFFKLHINK ILAKGVYQLY SDKEQKNRNA VIVYSGGDDV FVVGGWDDII
GFAIDLHTSL KKFSQGKLTI SAGIGIYPEK YPIAAMAKQT GELEDISKKF RNGEKNAVTL
FDDTSTYNWD EFIDCVLGEK LKAIKEFISV DGVHSKAMLY KMLTLIRSKK EENRLNIARF
AYLIARLRPN EKNTDENKLQ ERLNAYNNFA KKMYNWIQSP RDCRQLVTAI YIYVYMNRER
EVNGNDR
//
