ID R6PB61_9FIRM Unreviewed; 1193 AA.
AC R6PB61;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=BN582_00981 {ECO:0000313|EMBL:CDC20750.1};
OS Eubacterium sp. CAG:274.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262888 {ECO:0000313|EMBL:CDC20750.1, ECO:0000313|Proteomes:UP000017904};
RN [1] {ECO:0000313|EMBL:CDC20750.1, ECO:0000313|Proteomes:UP000017904}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:274 {ECO:0000313|Proteomes:UP000017904};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC20750.1}.
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DR EMBL; CBEX010000085; CDC20750.1; -; Genomic_DNA.
DR AlphaFoldDB; R6PB61; -.
DR STRING; 1262888.BN582_00981; -.
DR Proteomes; UP000017904; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 2.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 6.10.140.1720; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 2.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000017904}.
FT DOMAIN 525..642
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 227..254
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 290..457
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 684..718
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 761..984
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1193 AA; 136686 MW; F10BABBD70776F36 CRC64;
MYLKSLELQG FKSFPEKIKL DFNKGITAVV GPNGSGKSNI ADAVRWVLGE KSAKSLRGNK
MEDIIFNGTE NRKPLSFAEV SMIMDNSDKK LNLDYPEVTV TRRVYRSGES DYLLNGTKCR
AKDILELFMD TGVGKEGYSI IGQGRIDEIL SNKSEDRRML FEEAAGIVKY RTRSFEASNK
LAKERENLVR VNDIIATLET QVGPLEVQAE KAKKFISLSN KLKTVEVNRF VIEADRFEND
IKEVEKSISQ LGNDVLRERR QEEVLQKKRT SLKDDLSNVD LQYEENSNSI GEKRSQVEQK
ENDIKMCESE IQHFNENIER LNKSIDQNKK AIEDKNNESD ALDAKIVAKT LEAERKKKSY
EEKKSAYTDL ETKVTESEEL FNRFNSDIRD KMNRSADISS EISKINAKLS QLKDRKNTVS
EDISVLNGQL KEKEIALAVE EQKITRIDNE IEKISNNIEN DNVTLSELSG KINETKKKQL
DMTKSIQDKQ SRLRILSELE NSYEGYYGGV KAVLSQRDKK ISGFEGICGA VGELITLDKK
YETAIEIALG GAVQNIVAKN ENDVKKAISY LKTNNKGRAT FLPMTAIKPK TINNKTDILK
NTGVIGIAKE LISYDVQYEN IMSSLLERVI IVDTIDNGIA LSKKTNYSYK VVTLDGELFN
VGGSMTGGSI SKRSTGIFSR GREIGELREN LKVLVSEYNE LNSELDSMNN SITESNDNLK
KSNEMLQSLH INRARSVAEV TKSKEYVDDY KKRIEYSDVE SEKLESTILE DEKQVKQYEN
DLEAITDEIN SVNEKIQEYQ SKIQENRDIR ESSIREINDL KLDINQINNE IYNFNYNKKR
IETEVMELNT GIENFKSEIL DYENQIANKE KNKQSIFENT EQLKEEYSKF IKMQEELINY
KNEVNKNLDE LEKSIQRQTE TKNAIEKQLS RFEIKKEQLE NERKNLYNNM WEEYEITYVV
AKNYERLDMS SEDLVKEERN LKNQMKALGN VNMNAVEEYA EVSEKYQFLI KNRDDIKQSE
EKLIGIIEQL NVLMEEQFRE QFKVISDNFA ETFKEMFGGG EASLKLSNDQ DILNCGIDII
VQPPGKTLQN MMLLSGGEKA LTAISLLFAI LKMKPSPFCI LDEIEAALDD ANVNRYADYL
KNFVDDTQFI VITHRKGTME AADILYGVTM QEKGISKLVS VKFDENYNLD KEA
//
