ID R6PHJ4_9FIRM Unreviewed; 607 AA.
AC R6PHJ4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN662_01308 {ECO:0000313|EMBL:CDC09237.1};
OS Roseburia sp. CAG:45.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262947 {ECO:0000313|EMBL:CDC09237.1, ECO:0000313|Proteomes:UP000018173};
RN [1] {ECO:0000313|EMBL:CDC09237.1, ECO:0000313|Proteomes:UP000018173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:45 {ECO:0000313|Proteomes:UP000018173};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC09237.1}.
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DR EMBL; CBET010000015; CDC09237.1; -; Genomic_DNA.
DR AlphaFoldDB; R6PHJ4; -.
DR Proteomes; UP000018173; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CDC09237.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018173};
KW Transferase {ECO:0000313|EMBL:CDC09237.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 476..583
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 586..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 354..381
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 607 AA; 69263 MW; 98822080606BB929 CRC64;
MMQNISAWMD IQSLLMTVLS AMTIVTTIVM GLLIYSRFKM SVKETAISNA ESRIESTVDQ
VNNELRNMRQ ICNAVNYNIV QEYDISDQEF SRQFSLLYEV NNDKLQSMAL YDSDGKIIAA
EPVATREKNQ KVTEQDWYKS ATDEIENIHI STPHIQDLFG NETYQYNWVV SLSSLVDMNH
GDTPDSGVLL VDMKYSMIEE VLDNLNEAAG ETYYYLCTDD GEILYHPRKA EIDRGFFTED
SSTAAGYADG TYEISVNGEK SNIVVNSLSY TGWKLVGVVP EGVQTASINK FRYYIIATAI
ILLMMLFVVN KIMAKKISKP ILKLDESVKS YETGEKTEIY IGGTSEIRHL AYSVQNSYKQ
IEQLMEEIIR QQNKRRKSEM DALQSQINPH FLYNTLESIT WMVEANKNEE AVFMISELAK
LLRISLSKGK TVIRISEELQ HSKSYMNIQQ IRYKDRFQVE FLIDKNVEEC CTVKLVVQPL
LENAIYYGVG NMDEDEGGKI IVRGEQKGND IFLSVEDNGM GMSQEVVDNL LSNSEKVPKH
GSGVGLINVH TRIQLMFGKE YGLKIYSEPD EGTKAVIHIP AIPYSEEKRG ELENQNRKRE
RVEDEKK
//
