ID   R6RFS4_9FIRM            Unreviewed;       287 AA.
AC   R6RFS4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=4-hydroxy-3-methylbut-2-enyl diphosphate reductase {ECO:0000313|EMBL:CDC41806.1};
GN   ORFNames=BN661_01002 {ECO:0000313|EMBL:CDC41806.1};
OS   Firmicutes bacterium CAG:449.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263023 {ECO:0000313|EMBL:CDC41806.1, ECO:0000313|Proteomes:UP000018133};
RN   [1] {ECO:0000313|EMBL:CDC41806.1, ECO:0000313|Proteomes:UP000018133}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:449 {ECO:0000313|Proteomes:UP000018133};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC41806.1}.
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DR   EMBL; CBFH010000114; CDC41806.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6RFS4; -.
DR   STRING; 1263023.BN661_01002; -.
DR   Proteomes; UP000018133; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0051745; F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0019288; P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway; IEA:InterPro.
DR   Gene3D; 3.40.50.11270; -; 1.
DR   Gene3D; 3.40.1010.20; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain; 2.
DR   InterPro; IPR003451; LytB/IspH.
DR   NCBIfam; TIGR00216; ispH_lytB; 1.
DR   PANTHER; PTHR30426; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   PANTHER; PTHR30426:SF0; 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE; 1.
DR   Pfam; PF02401; LYTB; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018133}.
SQ   SEQUENCE   287 AA;  32540 MW;  6E174928E91C8BAF CRC64;
     MEIKIAKNYG FCAGVKNALE IVNKTVLTSK DKKIYMLNKI VHNQNVIEQI KNLGVIILDD
     SSLTNEEKIK SISEGILIFS AHGHDKKLDL LAKKQNLEIV DTTCKKVLLN IKQIQNALLE
     NKDVVYIGIR NHPETEASLA ISDKIIFLDF FSPDYSKLNN LKNISIHNQT TLIQDDLIKI
     YTKIKQICQN VEVHNDICFA TSLRQKSLLE VTDEDLIIII GDKISSNSTR LYEVGKSLYP
     NRTVLQINSL EELTKFDLSK YKKGFITAGA STPDEVINPI IKYLQNY
//