ID R6RIW6_9FIRM Unreviewed; 454 AA.
AC R6RIW6;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2 6-diaminopimelate ligase {ECO:0000313|EMBL:CDC45274.1};
GN ORFNames=BN661_00223 {ECO:0000313|EMBL:CDC45274.1};
OS Firmicutes bacterium CAG:449.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263023 {ECO:0000313|EMBL:CDC45274.1, ECO:0000313|Proteomes:UP000018133};
RN [1] {ECO:0000313|EMBL:CDC45274.1, ECO:0000313|Proteomes:UP000018133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:449 {ECO:0000313|Proteomes:UP000018133};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752, ECO:0000256|RuleBase:RU004135}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004135}.
CC -!- SIMILARITY: Belongs to the MurCDEF family. MurE subfamily.
CC {ECO:0000256|ARBA:ARBA00005898}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC45274.1}.
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DR EMBL; CBFH010000389; CDC45274.1; -; Genomic_DNA.
DR AlphaFoldDB; R6RIW6; -.
DR STRING; 1263023.BN661_00223; -.
DR UniPathway; UPA00219; -.
DR Proteomes; UP000018133; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR InterPro; IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
DR NCBIfam; TIGR01085; murE; 1.
DR PANTHER; PTHR23135; MUR LIGASE FAMILY MEMBER; 1.
DR PANTHER; PTHR23135:SF4; UDP-N-ACETYLMURAMOYL-L-ALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE MURE HOMOLOG, CHLOROPLASTIC; 1.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|RuleBase:RU004135};
KW Cell division {ECO:0000256|RuleBase:RU004135};
KW Cell shape {ECO:0000256|RuleBase:RU004135};
KW Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU004135};
KW Ligase {ECO:0000313|EMBL:CDC45274.1};
KW Peptidoglycan synthesis {ECO:0000256|RuleBase:RU004135};
KW Reference proteome {ECO:0000313|Proteomes:UP000018133}.
FT DOMAIN 100..241
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
FT DOMAIN 306..386
FT /note="Mur ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02875"
SQ SEQUENCE 454 AA; 53265 MW; 9B60CB93090A9B76 CRC64;
MQIKELLNYL KIASNDERII KSVVTSTKDV EENCVLILTK GHTIDPNLLL NKDIIKKCLV
ILSDQKNENV IFIENLKDRV FEILDFVYFR FKHNFKIIGI TGSEGKSSLS NIIYQGLKVI
NKKVMLISNY RYDKDVFLSE LTTPTSKDII LAMEECQKRK YEYLIFEVSC IGISEKRVSS
KIFDYLFLTS LEVDHLDYYQ NIYQYHLSKI SLLQNNIKGK KFILKSAFDK YPHLFEKITN
LKIIDENEII LKKSSLNHQV FSYKHVDYYT HLIFKQNRIN LTFLIEFLIS IHAFNFKYII
KKIKRVEGRL DLVHTRPYVL IDNAHSKQSV ENVLKEISLF KQNKLICVIG AGGNRDKTKR
SEYGKSCLKY CEEIYVCNDN PRKEDPYKIA SMIALNNDFK IILNRKKAIS EAIKNASKDD
IIVILGRGNE EYQIINDKRI YLNDYEEVKK CFIK
//
