ID   R6S1J8_9FIRM            Unreviewed;       468 AA.
AC   R6S1J8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=BN606_02118 {ECO:0000313|EMBL:CDC40492.1};
OS   Butyrivibrio sp. CAG:318.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Butyrivibrio; environmental samples.
OX   NCBI_TaxID=1262761 {ECO:0000313|EMBL:CDC40492.1, ECO:0000313|Proteomes:UP000018075};
RN   [1] {ECO:0000313|EMBL:CDC40492.1, ECO:0000313|Proteomes:UP000018075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:318 {ECO:0000313|Proteomes:UP000018075};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC40492.1}.
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DR   EMBL; CBFF010000086; CDC40492.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6S1J8; -.
DR   STRING; 1262761.BN606_02118; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000018075; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06113; citrate_synt_like_1_2; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018075};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        329
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        388
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   468 AA;  53039 MW;  FBBD3587A45B3947 CRC64;
     MTLENVNDFT EKYAAKCVRE QKIDPALYDQ YGVKRGLRDK NGKGVLSGLT SISLIKSYNE
     IDGKTIPCDG ELYYRGYNIM DIVRGFRSDN RFGFEETAYL LLFGDLPTKA ELAEFKDILN
     ASRRLPTNFT RDVIMKAPSG DIMNSLTKSI LTLASYDNNV SDLSIDNVMR QCLMLISVLP
     MLAVYGYHAY NHYERDDSLY IHRPDNSLSF AENILRLLRP DKSYTDVEAK VLDAALVLHM
     EHGGGNNSTF TTRVVTSSGS DTYSVVAAAL SSLKGPKHGG ANIKVVKMMN DLKEHVSDLK
     DEDMIRDYLK KILRKEAFDK SGLIYGIGHA VYSISDPRAR IFKSFVEELA TETHHNDEFA
     LYSMIERIAP EVISESCHIY KGVSANVDFY SGFVYNMLNI PLELYTPIFA IARIVGWSAH
     RMEELINVDK IIRPAYKSIM VPKMYENLDA RNKKLNTADD IRHRITMK
//