ID R6V002_9FIRM Unreviewed; 570 AA.
AC R6V002;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BN546_01152 {ECO:0000313|EMBL:CDC91513.1};
OS Firmicutes bacterium CAG:227.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263010 {ECO:0000313|EMBL:CDC91513.1, ECO:0000313|Proteomes:UP000018294};
RN [1] {ECO:0000313|EMBL:CDC91513.1, ECO:0000313|Proteomes:UP000018294}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:227 {ECO:0000313|Proteomes:UP000018294};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC91513.1}.
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DR EMBL; CBGC010000050; CDC91513.1; -; Genomic_DNA.
DR AlphaFoldDB; R6V002; -.
DR STRING; 1263010.BN546_01152; -.
DR Proteomes; UP000018294; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDC91513.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018294};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 9..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..354
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 464..568
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 570 AA; 65461 MW; 95B4A72B14D25197 CRC64;
MKQSIRKKVL LAILLVTILT SCCITVVFYF RSASMIEKNY TETVYSRVRQ TMESFDNSMK
ELYYKNIEIA GKEELQREIK QYRESNNADE LESLAEILRA CKKNEDRLSS IDLILPEEQI
AVTSEDFPVY KREIPKEEIQ TIKEMEEKTA RPVMVKNSVH ENRTQVTEIQ SIYDEEQNIL
AYLLLNVEER TLYYQYIDPI YDENMNQALV YDENKVVVTG MNSKEAGKTC AEEMCLKQNG
IFQKEKGVIV IGYKGAFSGC QLSIAVQRNA ILRQLRQMQI FLIVIVLVFL FVAIVLAGSL
TRAIYRPIKK LTDTVEQVGE GDLSLRAEVE TGDEIGILCR EFNVMLDDIQ ELIQKVIEEE
RLKKDAELEA LQYQITPHFM YNTLNSIKFA ALIRGEKELG GLIGDFVELL QATISKKGTF
LTVADEFHIL NNYVHLQEFR YQGSFRVRYE MEEGAGGCYI PRLILQPLVE NAILHGIDMK
EKNGEIILRA KLEQDRLRLF VIDNGRGMTK EQIDTLLHSK AKKTNGLSAI GVPNIKERLE
LYYGDKGEMV YQSSENGTTV EIFLPAKKEL
//
