ID R6VQS2_9FIRM Unreviewed; 558 AA.
AC R6VQS2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Efflux transporter RND family MFP subunit {ECO:0000313|EMBL:CDC96624.1};
GN ORFNames=BN635_00487 {ECO:0000313|EMBL:CDC96624.1};
OS Roseburia sp. CAG:380.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262946 {ECO:0000313|EMBL:CDC96624.1, ECO:0000313|Proteomes:UP000017909};
RN [1] {ECO:0000313|EMBL:CDC96624.1, ECO:0000313|Proteomes:UP000017909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:380 {ECO:0000313|Proteomes:UP000017909};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC96624.1}.
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DR EMBL; CBGD010000319; CDC96624.1; -; Genomic_DNA.
DR AlphaFoldDB; R6VQS2; -.
DR STRING; 1262946.BN635_00487; -.
DR Proteomes; UP000017909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 2.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR PRINTS; PR01490; RTXTOXIND.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017909};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..118
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 195..349
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 208..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 558 AA; 58021 MW; 72751035EFB21A80 CRC64;
MKKKRGKKFK LIVGGVAAAV VVVGVVIGVR MIRAKNASPA GAVKQSTTTL TKMDLTDSIS
ASGTIESKKT RSVTAQVNDV TVQKIYVKVG DEVKKGDKLV SFDSDSLSES LSEAQDSLQD
VQSSAASEVE SAQEQYDTAV SDRNYNNAKA AKNLQKAVKA RDTAKKAVKT AKTKLKQVKK
KAGAKNSQDV TTAQEALTKA QEAYEQAKTA VETARDNKND TARQNKSSVT QAQTALKNAQ
TNRKKNVKEA QKQVTSAQEA VAKCAVTAPM DGVVTSLNVS AGDTYTGGTI VQLDDTSGYT
ITTSVDEYDI SNVKKGQRVV ILTEATDEDE LEGVVTFVAP STGSTSTTTS ASSGNGADAG
NSSSDGYEVR IRIKTTDSRI KMGMTAKCSI VRDEAKDVFA VPYDAVSENA DGTYYITVVD
GSGSSTGYTT QSGDNSQDSS DNSGQSGDSG QRGKMGNPPG QDETNASDDS TKGTAKTRQI
AVTKGMETDY YVEISGDDLE EGLEVVMPTD KVSDKSSSSD SQSGFGSMNG MGGGMPDSGG
MGGSGSKGGF GGGPGGGK
//
