ID   R6VRM5_9FIRM            Unreviewed;       701 AA.
AC   R6VRM5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Glutamine synthetase {ECO:0000256|ARBA:ARBA00021364};
GN   ORFNames=BN546_00843 {ECO:0000313|EMBL:CDC94761.1};
OS   Firmicutes bacterium CAG:227.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263010 {ECO:0000313|EMBL:CDC94761.1, ECO:0000313|Proteomes:UP000018294};
RN   [1] {ECO:0000313|EMBL:CDC94761.1, ECO:0000313|Proteomes:UP000018294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:227 {ECO:0000313|Proteomes:UP000018294};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01330, ECO:0000256|RuleBase:RU000384}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC94761.1}.
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DR   EMBL; CBGC010000261; CDC94761.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6VRM5; -.
DR   STRING; 1263010.BN546_00843; -.
DR   Proteomes; UP000018294; Unassembled WGS sequence.
DR   GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1560; -; 1.
DR   Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR   InterPro; IPR040577; Gln-synt_C.
DR   InterPro; IPR008147; Gln_synt_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR022147; GSIII_N.
DR   PANTHER; PTHR42974; GLUTAMINE SYNTHETASE; 1.
DR   PANTHER; PTHR42974:SF1; TYPE-3 GLUTAMINE SYNTHETASE; 1.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   Pfam; PF18318; Gln-synt_C-ter; 1.
DR   Pfam; PF12437; GSIII_N; 1.
DR   SMART; SM01230; Gln-synt_C; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
DR   PROSITE; PS51986; GS_BETA_GRASP; 1.
DR   PROSITE; PS51987; GS_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018294}.
FT   DOMAIN          63..152
FT                   /note="GS beta-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS51986"
FT   DOMAIN          157..589
FT                   /note="GS catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51987"
SQ   SEQUENCE   701 AA;  77970 MW;  CA554AC3AEBC7B4F CRC64;
     MSKDIPTLYG SLVFSDKVMR NKLPKDVYKA LRKTIENGTH LELDVANSVA VAMKEWAVEN
     GATHFTHWFQ PMTGFTAEKH DSFITPVGEG EVIMEFSGKE LVKGEPDASS FPSGGLRATF
     EARGYTNWDP TSPAFIKDNT LYIPTAFCSW SGEALDKKTP LLRSMEALNK EAVKILHLLG
     NTEVTSVITT VGPEQEYFLI PKELYAKRRD LIFTGRTLFG ASAPKGQEME DHYFGALKPR
     VAAYMHDLDE ELWKLGIPAK TKHNEVAPAQ HELAPVFDTT NVAVDHNQLT MEIMKKVAEK
     HDLVCLLHEK PFDGINGSGK HNNWSVSTNT GVNLLDPGKT PAENIQFLVF LVAVIKAVDE
     YADLMRVSAS GAGNDHRLGA NEAPPAIVSI FIGDELTEIL KSIEEDKFFN AHKTIQMDIG
     AHVLPHFTKD TTDRNRTSPF AFTGNKFEFR MLGSSASVAS PNVVLNTAVA EALAQFYKEL
     EGTAPEDMET AVHELIKRAI RKHKKVIFNG NGYTDEWIKE AEERGLYNLV STPDALPQFI
     ADKNIELFTK HSVFTKEEIY SRYEILLENY VKTINIESKT LQEMLTKDFI PAVNGYAAEV
     AVNANEKKAL IEGLATTAEE SIVKELTEAS NTLSAKVAEL KAVTEKADAA AEEDMQKAAE
     SFHKDVLTLM DEMKDVANAA EEKIPDEELP YPTYDQMLFY V
//