ID   R6WBN2_9FIRM            Unreviewed;       730 AA.
AC   R6WBN2;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CDC91622.1};
GN   ORFNames=BN546_01261 {ECO:0000313|EMBL:CDC91622.1};
OS   Firmicutes bacterium CAG:227.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263010 {ECO:0000313|EMBL:CDC91622.1, ECO:0000313|Proteomes:UP000018294};
RN   [1] {ECO:0000313|EMBL:CDC91622.1, ECO:0000313|Proteomes:UP000018294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:227 {ECO:0000313|Proteomes:UP000018294};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC91622.1}.
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DR   EMBL; CBGC010000053; CDC91622.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6WBN2; -.
DR   STRING; 1263010.BN546_01261; -.
DR   Proteomes; UP000018294; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018294};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          69..233
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          286..606
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          667..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        669..687
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        695..730
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  80708 MW;  84FB7AD631709F17 CRC64;
     MKRQQKKGTK RLTKKMKTKL VGLLIVILLA LVALIFRITY ISIKSGDRYT RQVLTQSQQQ
     YESTTVPFKR GDILDRNGNT LATSVKVYNV ILDCSLVNSD KKYRKPTVDA LSDYLGIDSS
     VVEAKLDDES TANSQYQILK KVSMDERKHF LEMNEITDDN KDTLKRSEYK RRSRVKGVWF
     EEHYQREYPF HALASTVIGF SSVNNTASLG IEGYYSSTLN GTDGKKYGYL NSDDIMEQNI
     VDAVDGKTVV STIDVNIQSI VEKYISAFNE KLRNNAYEGD GAENIGVIVE NPNNGEILAM
     AGKNTFDLND PRAAYANRTD LSDEEISAGL DSLWENFCVS SNYELGSVIK PIIVASALES
     GAVSDSDVFI CDGGEQIGND YVRCAVYPYA HGTETLGEVI QNSCNDGMMA IGRKMGAALL
     LDYQSRFNFG SRTGIDLPNE SSGAIYTLDQ MKDMELASTT FGQGFTSTMI QEISAVSAVI
     NGGTYYQPHV VKEIKSQEDG SVLKTNEGNV LKQIVSSDVS EKIREYMGMS VTSGTSRKSK
     VQGYSMGGKT GTAEILSTEE KDYLVSFIGF APLDTPQVVV YVVVDRPNVE EQADSSYAQY
     IAQAILDEIL PYMNIYPDEE TEETTKLWDG FKGVLRLDDS EVEVNEPIVQ TEGSETGTDN
     AQDIEVVQDE SGSSEEYNDE ESDGVASENA GYEETVSEDV SDEEDTSSDT SNEEDTSNQD
     ESTYEEDEGE
//