ID R6WBY1_9FIRM Unreviewed; 1186 AA.
AC R6WBY1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=BN605_01939 {ECO:0000313|EMBL:CDD08583.1};
OS Dorea sp. CAG:317.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=1262873 {ECO:0000313|EMBL:CDD08583.1, ECO:0000313|Proteomes:UP000018262};
RN [1] {ECO:0000313|EMBL:CDD08583.1, ECO:0000313|Proteomes:UP000018262}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:317 {ECO:0000313|Proteomes:UP000018262};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD08583.1}.
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DR EMBL; CBGJ010000112; CDD08583.1; -; Genomic_DNA.
DR AlphaFoldDB; R6WBY1; -.
DR STRING; 1262873.BN605_01939; -.
DR Proteomes; UP000018262; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR CDD; cd03278; ABC_SMC_barmotin; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000018262}.
FT DOMAIN 521..638
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 248..366
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 402..478
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 672..769
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 833..937
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 1005..1032
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1186 AA; 136293 MW; FBF63F7218EC2009 CRC64;
MYLKSIEVQG FKSFAHKLKF DFHNGITGIV GPNGSGKSNV ADAVRWVLGE QRVKQLRGGT
MQDVIFSGTE NRKPLSYASV AITLDNSDHQ LPIDYEEVTV ARKLYRSGES EYLINGSTCR
LKDVNELFYD TGIGKEGYSI IGQGQIDKIL SGKPEERREL FDEAAGIVKF KRRKLLSVKK
LEEERQNLLR VNDILAELEK QIGPLERQSE KAKEYLKKKE SLKTYDINMF LLETERIREL
LKSTEGKLAL TQEELSEAGI RYEDMKQEYE AVEEQVDTID ESIEHAKNQL NETTMLKQQL
ENKIALLKEQ INSAHMNDEH YAQRALTIQS ETGTREQQLK ELGKERESLQ TELKERKAVE
DAAREELIEV QSRIAALSDG IEKNKSDIIE LLNNRASTKA KIQKYDTMLE QIQVRKAQIN
QRILEARSEV ELQNEEKNKY TGELQNISDQ IIRLSDEHHA YEKKIEDIQR ILAKETEKFR
IGQTAYHREQ SRLESLKNIT ERYDGYGNSI RRVMDNKKQE PGLLGVVADI VKVEKEYEVA
VETALGGSIQ NIVTEDEDTA KRMIQFLKKN KFGRATFLPL TSIQSYGAFH KPEALKENGV
IGIASTLVNV DAKYRDLAGY LLGRTLVVDH IDHGTAIARK YKQTIRIVTL EGELINPGGS
MTGGAFKNSS NLLSRRREIE EFEKTVKQLK SEMDQLEEYC NGLRKERAGY YEEIESLKEK
LQKAYVIQNT AKMNVDQAEG RIRSIFNTLE DIESEAENLD RQITDIVDNQ ESITVELDTS
EHLEEELSGK IDNEQSILEK ERELEAEKQK TVEEIHLVSA GLEQKEAFVV ENVTRIRDEL
EKFAQEMKEL EESKSGTSKE IEEKEEQIAD LRQTIENSKE LFTEIQQEIE KFKKDREMLN
QQHKTFLQKR EELSKHMSQL DKEVFRLESQ KEGYEEASEK QINYMWEEYE ITYNHALELR
DENLTDLSKM KKRISELKGE IRSLGDVNVN AIEDYKNVSE RYEFLKTQHD DLVEAEATLE
QIIEELDAAM RKQFKEQFAK ICSEFDTVFK ELFGGGKGTL ELMEDEDILE AGIRIIAQPP
GKKLQNMMQL SGGEKALTAI ALLFAIQNLK PSPFCLLDEI EAALDDNNVT RFAKYLHKLT
KYTQFIVITH RRGTMTAADR LYGITMQEKG VSTLVSVSLL EDELDA
//
