ID R6XKC4_9BACT Unreviewed; 1237 AA.
AC R6XKC4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=BN769_02116 {ECO:0000313|EMBL:CDD19524.1};
OS Prevotella sp. CAG:732.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262934 {ECO:0000313|EMBL:CDD19524.1, ECO:0000313|Proteomes:UP000018039};
RN [1] {ECO:0000313|EMBL:CDD19524.1, ECO:0000313|Proteomes:UP000018039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:732 {ECO:0000313|Proteomes:UP000018039};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD19524.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CBGP010000071; CDD19524.1; -; Genomic_DNA.
DR AlphaFoldDB; R6XKC4; -.
DR Proteomes; UP000018039; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000018039};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..82
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1237 AA; 140575 MW; D5A76AC0DB1FECB7 CRC64;
MEDFIHLHVH TQYSILDGQS KIPHLVDKAI KDGMKGMAVT DHGVMFGIKE LTDYCGKVNK
GRKKEGLEPF KPIIGCEMYV AHRRKEDKEK DKGDMSGYHL IVLAKNYNGY KNLIKLVSNS
WVDGYYMRPR TDRADLEKYH EDLIVCSACI AGEVPAKILK GDIEGAREAC EWYHNLFGDD
YYLELQRHKV PDIPGLLANR EAYELQQRAN KVLIEFAKEY GIKLICTNDC HFEDKETAEA
HDHLLCIATG KDLDDPNRMR YSKQEWFKTR EEMNEVFSDI PEALSNTLDI YNKVEIYSID
HGPIMPFFPI PESFGTEEQL RQKVSEEDLF KEFTSDENGQ NQLPPEEGQK VIDRLGGYDK
IYRIKFEAEY LKHLAYEGAK ERYGDPLPEN VDEHVNFELH VMKTMGFPGY FLIVSDFIRA
AREELGVVVG PGRGSAAGSV VAYCLGITKI DPLKYDLLFE RFLNPDRVNL PDIDTDFDDD
GRGKVLRWVM DKYGHENCAH IITYGSMATK NSIKDVARVE KLPLDKANAL CKAIPDRLPE
GAKMNLTNAI KYTPELRDAE YSTDPRESNT IKYAKMLEGT IRGTGIHACG FIICRDPISN
WVPVSTADDP DFPGLKTAVT QYDGHVIEST GLIKMDFLGL KTLSELKEAC KVVKQTLGED
VDLDHIPIDD TLTYELYQRG QTIGTFQFES PGMQKYLREL KPTVFEDLIA MNALYRPGPM
DYIPSFIARK NGQEEIKYDI PCMEKYLKDT YGITVYQEQV MLLSRQLANF TRGESDALRK
AMGKKKKDIV DAMKPKFIKQ GQENGHDPAI LEKIWGDWEK FASYAFNKSH ATCYSWVAYQ
TAYMKAHYPA EYMAALMTRR FAQITEITKL MEECQSMNIK TLGPDVNESY RAFGVNEHGE
IRFGLSAIKG MGAPAADAIV AERQKNGPYK DIFDFAQRVD FSNVNRKAFE SLALSGGFDS
FGIPREDFFG KDNKGVVFLD SLVKYGQLYQ QEQREVQNSL FGEEDAAEIA TPPIPKAEPW
STIERLNRER ELVGIYLSAH PLDDYSIILN SMCNTHCSEL GDKAELAKKA DILFGGIVTG
VKSKFTKTGK PCGFVTLEDF EGSGELALFG EDWGMWRGVL IEGATVYVTA KCAPRYANSD
YLDFRISSID YMQTVKEKRI ERITITVDSD IIDETVVNDF KTMLQEDAAG KTQLFFQIHD
VETNNFIMLR AQDRTVNVGK ELIHYIDSNP KMAYHIN
//
