ID R6XM24_9FIRM Unreviewed; 583 AA.
AC R6XM24;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Putative protease CspB {ECO:0000313|EMBL:CDD07382.1};
GN ORFNames=BN605_00853 {ECO:0000313|EMBL:CDD07382.1};
OS Dorea sp. CAG:317.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=1262873 {ECO:0000313|EMBL:CDD07382.1, ECO:0000313|Proteomes:UP000018262};
RN [1] {ECO:0000313|EMBL:CDD07382.1, ECO:0000313|Proteomes:UP000018262}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:317 {ECO:0000313|Proteomes:UP000018262};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD07382.1}.
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DR EMBL; CBGJ010000058; CDD07382.1; -; Genomic_DNA.
DR AlphaFoldDB; R6XM24; -.
DR STRING; 1262873.BN605_00853; -.
DR Proteomes; UP000018262; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07478; Peptidases_S8_CspA-like; 1.
DR Gene3D; 2.60.120.1290; -; 1.
DR Gene3D; 3.30.70.2980; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR041365; CspB_prodomain.
DR InterPro; IPR034045; Pep_S8_CspA-like.
DR InterPro; IPR017310; Pept_S8A_subtilisin_clostridia.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF18425; CspB_prodomain; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PIRSF; PIRSF037894; Subtilisin_rel_CspABC; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000018262};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 4..91
FT /note="Csp protease B prodomain"
FT /evidence="ECO:0000259|Pfam:PF18425"
FT DOMAIN 118..308
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 446..573
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 127
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 201
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 517
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 583 AA; 64264 MW; B0B987BF39B3F18F CRC64;
MESQKRENIL NLALEATGEE RERSIELDVG FAKEEKEWTL IIKYSGDLQE VRGIAKRVTP
LMGGYAVIVI KEDRINTLTE FPQIEYIEKP KRLFFEVMEG KRVSCIYPVQ NPPLSLSGKK
IFVAILDSGI DYEREDFRNS DGTTRIRALW DQSLQNGVDG IAPKGFEVGV EYNQEEINKA
LQAGTNEERK QIVKSQDFSG HGTAVAGVAA GRGSVGFPQY RGVAPESELL VVKLGTPAKD
GFPRTTELMM GLDYVMRKSL EYRRPVAINL SFGNTYGSHD GTSLLERFID DISGVWKNSI
CIGTGNESVS AGHTSGKLQD DKEEVIELAV QNRQPSLNVQ IWKEYTDFMD ISLISPSGIR
VGPIPEKLGM QRFTMGETEI LLYYGEPSPF SVAQEIFIDM LPVNDYMNQG VWKIVLTPRE
IVSGRYELWL PSEAALNKGT GFLYPKNTTT LTIPSTSWRA ISVGAYDGRT FSYADFSGRG
PLRGGSGMLL KPDLVAPGVD ITTVAAGGGY ASFTGTSFAT PFVTGAAALL MEWGIVNGND
PYLYGEKVKA YLRRGARPLP GFDVYPNPQV GWGALCVRES LPT
//
