ID   R6XMR5_9FIRM            Unreviewed;       595 AA.
AC   R6XMR5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Creatinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN605_01049 {ECO:0000313|EMBL:CDD07602.1};
OS   Dorea sp. CAG:317.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX   NCBI_TaxID=1262873 {ECO:0000313|EMBL:CDD07602.1, ECO:0000313|Proteomes:UP000018262};
RN   [1] {ECO:0000313|EMBL:CDD07602.1, ECO:0000313|Proteomes:UP000018262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:317 {ECO:0000313|Proteomes:UP000018262};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD07602.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBGJ010000070; CDD07602.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6XMR5; -.
DR   STRING; 1262873.BN605_01049; -.
DR   Proteomes; UP000018262; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018262}.
FT   DOMAIN          6..133
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          311..526
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          535..595
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   595 AA;  66690 MW;  9890203E42E7D1B6 CRC64;
     MSIAERITAL RALMADRGYD VYMVPTDDNH QSEYVGEHFK ARAFITGFTG SAGTAVITKD
     EAGLWTDGRY FVQAAQQLEG SGVKLFKMGE PGVPTVEEYI ANVIPENGTL GFDGRVVAMG
     EGQALVEAVA PKHAKINYSE DLIDLIWKDR PALSEKPAFA LGEEYTGEST ASKLARIREA
     MKEHGATVHV IAALDDVCWT TNLRGDDIEY FPLLLSYAVI TMDDMKLYID ERKLTDEMKD
     ALAKDHISLR PYNAIYEDVK ELSSSDIILV DPARLNYALY NNLPKEAKVV EAMNPTVLMK
     AMKNDVEIKN IINAHIKDGV AITRFMYWLK KNIGKIEITE ISAAEKLEEF RKEQEGYLWQ
     SFEPICGSGE HGAIVHYAAT EETNVPVVTD GLFLTDTGGG YMEGSTDITR TFAFGKLSDQ
     MKEDFTTVLK CNLHLARAVF LYGTTGYNLD VLARIPAWER GLNFNHGTGH GVGYLMNIHE
     APTGFRCAIR DREKQPIEAG MILTDEPGLY IEGSHGIRTE NELLVRKGQK TEYGQFLYFE
     PITYAPIDLD AVIPEQLTQE DKEQLNAYHA KVYELVGPRL NNEEREWLKE YTRAI
//