ID   R6XPJ6_9FIRM            Unreviewed;       380 AA.
AC   R6XPJ6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=Site-specific recombinase phage integrase family {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN605_00121 {ECO:0000313|EMBL:CDD08252.1};
OS   Dorea sp. CAG:317.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX   NCBI_TaxID=1262873 {ECO:0000313|EMBL:CDD08252.1, ECO:0000313|Proteomes:UP000018262};
RN   [1] {ECO:0000313|EMBL:CDD08252.1, ECO:0000313|Proteomes:UP000018262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:317 {ECO:0000313|Proteomes:UP000018262};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000256|ARBA:ARBA00008857}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD08252.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBGJ010000093; CDD08252.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6XPJ6; -.
DR   STRING; 1262873.BN605_00121; -.
DR   Proteomes; UP000018262; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008907; F:integrase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   CDD; cd01189; INT_ICEBs1_C_like; 1.
DR   Gene3D; 1.10.150.130; -; 1.
DR   Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR   InterPro; IPR044068; CB.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   InterPro; IPR010998; Integrase_recombinase_N.
DR   InterPro; IPR004191; Integrase_Tn916-type_DNA-bd_N.
DR   InterPro; IPR025269; SAM-like_dom.
DR   PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR   PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR   Pfam; PF02920; Integrase_DNA; 1.
DR   Pfam; PF13102; Phage_int_SAM_5; 1.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR   PROSITE; PS51900; CB; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000018262}.
FT   DOMAIN          47..127
FT                   /note="Core-binding (CB)"
FT                   /evidence="ECO:0000259|PROSITE:PS51900"
FT   DOMAIN          149..372
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000259|PROSITE:PS51898"
SQ   SEQUENCE   380 AA;  44559 MW;  F43C9A94E18D8D1B CRC64;
     MYRYKDERTG RRLAVYSPDL AELRKKEKEI EKDQSEGILT DTQCKNMTLN DLFEIHMDTR
     KLAESTQANY RRMWNSLVRN ELGQMKVVQV RPSHVRLFYS RLSKQKYSHS TIKFLHNMIL
     PSFEVAVDDD IIRKNPAKRT LGDYGEPEKK RTALSFDQQK NLLNYVKNSE VFHIYLPLLQ
     VMIGTGLRCG ELIGLTWKDV DLKTRTVYVN HQLIYKNYGD GCDFHVTMPK TEAGIREIPM
     SKMVAKAFET QRRLNFQMGI PRDVKIEGLS NFVFMSRSGR PMMPTTVNFI LRDIVKAYNE
     EENERAKRER RKPEELPHIS AHILRHTACT RMAETDLDMK VVQYVMGHAN ISVTMEVYNH
     ITDRSRIERE IAKMDLVQIM
//