ID   R6XY58_9BACT            Unreviewed;       711 AA.
AC   R6XY58;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE            EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN   ORFNames=BN590_01046 {ECO:0000313|EMBL:CDD23959.1};
OS   Alistipes sp. CAG:29.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC   Alistipes.
OX   NCBI_TaxID=1262694 {ECO:0000313|EMBL:CDD23959.1, ECO:0000313|Proteomes:UP000018138};
RN   [1] {ECO:0000313|EMBL:CDD23959.1, ECO:0000313|Proteomes:UP000018138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:29 {ECO:0000313|Proteomes:UP000018138};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC         EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
CC   -!- SIMILARITY: Belongs to the peptidase S9A family.
CC       {ECO:0000256|ARBA:ARBA00005228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD23959.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBGS010000003; CDD23959.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6XY58; -.
DR   Proteomes; UP000018138; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR023302; Pept_S9A_N.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002470; Peptidase_S9A.
DR   PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR   PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   Pfam; PF02897; Peptidase_S9_N; 1.
DR   PRINTS; PR00862; PROLIGOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000313|EMBL:CDD23959.1}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..711
FT                   /note="prolyl oligopeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004437142"
FT   DOMAIN          33..432
FT                   /note="Peptidase S9A N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02897"
FT   DOMAIN          491..703
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   711 AA;  79056 MW;  EFE720355721863B CRC64;
     MMKLTRKAVA LAGAAAMMAS CNHMKQIKHM PYPETQRTDV VDDYFGTKVA DPYRWLEDDN
     SEATAAWVKA QNAVTQDYLS QIPFRDAIRG RLTQLWNYPK EGIPAKHGDA WYYFYNDGLQ
     NQSVLYRTTA PGAQGEVFLN PNTLSDDGTV ALSSVAFSKD GKYCACAVAE SGSDWVEIRV
     MNTADRTFTT DKINWVKFSG AEWAPDSKGF YYSAYDAPEK GVFSSQNQFQ KVYYHRLGTP
     QSADKLIYMD AEHPLRYFSA WPSKDGKWLF ISASEGTSGT EILYKKVSEP KFRTLLPGFD
     ADYALVECRD DRLYYITNKD AANNALMKVD LNDPSSITAV IPENEKSLLE NVTAAGGYFF
     ASYLQDAQGK VVQYGFDGKP VRDIELPGIC TAAGFDGDDE AAEIYYSVSG YTAPATIYKL
     DVASGESTLF KAPDVNFDPA LFTTEQVFYT SKDGTKVPMF ITHRKDLKLD GKNPCYLYAY
     GGFQINRTPG FRPSAIMFVE QGGVFCEANL RGGSEYGEAW HKAGMLENKQ NVFDDFIAAA
     EYLIANKYTS KDKLAIAGGS NGGLLVGACE VQRPDLYAVC LPAVGVMDML RYHKFTIGWG
     WAVEYGSSEN EEQFDYIYKY SPLHNIREGV QYPATLVTTA DHDDRVVPAH SFKFTAQMQH
     CQAGDAPILI RIESKAGHGA GKPTSKRIDE EADTYAFLFQ NIGVPYKPVA K
//