ID   R6Z5F5_9FIRM            Unreviewed;       591 AA.
AC   R6Z5F5;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=NlpC/P60 domain-containing protein {ECO:0000259|PROSITE:PS51935};
GN   ORFNames=BN600_00255 {ECO:0000313|EMBL:CDD36101.1};
OS   Roseburia sp. CAG:309.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262945 {ECO:0000313|EMBL:CDD36101.1, ECO:0000313|Proteomes:UP000018292};
RN   [1] {ECO:0000313|EMBL:CDD36101.1, ECO:0000313|Proteomes:UP000018292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:309 {ECO:0000313|Proteomes:UP000018292};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase C40 family.
CC       {ECO:0000256|ARBA:ARBA00007074}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD36101.1}.
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DR   EMBL; CBGX010000339; CDD36101.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6Z5F5; -.
DR   STRING; 1262945.BN600_00255; -.
DR   Proteomes; UP000018292; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd16891; CwlT-like; 1.
DR   Gene3D; 1.10.530.10; -; 1.
DR   Gene3D; 3.90.1720.10; endopeptidase domain like (from Nostoc punctiforme); 1.
DR   InterPro; IPR047194; CwlT-like_lysozyme.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR000064; NLP_P60_dom.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   Pfam; PF13702; Lysozyme_like; 1.
DR   Pfam; PF00877; NLPC_P60; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
DR   PROSITE; PS51935; NLPC_P60; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018292};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        226..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          445..590
FT                   /note="NlpC/P60"
FT                   /evidence="ECO:0000259|PROSITE:PS51935"
FT   REGION          52..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          181..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   591 AA;  65002 MW;  B445A862F1A895D4 CRC64;
     MADLKDTYGF TVEQKKALSH LTKKQMEKFK KLSRYDQKKI LRMAENITRQ EYARQKFQEK
     QGKSPNKKGS SQKAATFLKQ KKARSLSSAR RKSKSMVRTA MQPTEIMAKC IASFMGESGE
     QRENAASVGQ QQTVSNLHKP MQMTNQGLSD MRKVSHDVTD LFLRNKQADF QKQKAKISFF
     SGRKEKREEK RQDEKRQQVK SMGKKAASMT GKIIKEVAVT VVQTNAALFL VVAAAILIMV
     IILIPVILLV GGSGESSQEA ASAQTEVILS AQTESYRPLV IAACAKYDIS PYVDLALAVI
     EQESGGNPPD VMQAEQSYYN KKPPIDSAEE SIDCGVHELS DCLKSAGAKG AGDLTNISLA
     LQAYNFGNGY LAWARKNYQG YTKTNAKIFS AKMCKEKGYS SYGDVDYVPH VLRYYKVAGS
     GDVLTVSNKK ALKILKELEN NNQADPKVWA VIEKGASLIG NTTYSMSARQ ADGRETPSVL
     DCSSFTAWCF AKNGFAGIPF SATTATFRQS LLFKDVSAKD LQVGDIGLKS KTAGTGGANH
     VGIYCGKLKN GSKVWLHCTS SSSTSLTGNT SGAMFGAYTN FTYFRRFRQF E
//