ID R6ZR83_9CLOT Unreviewed; 529 AA.
AC R6ZR83;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Periplasmic glycine betaine/choline-binding (Lipo)protein of an ABC-type transport system (Osmoprotectant binding protein) {ECO:0000313|EMBL:CDD43546.1};
GN ORFNames=BN593_02093 {ECO:0000313|EMBL:CDD43546.1};
OS Clostridium sp. CAG:299.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262792 {ECO:0000313|EMBL:CDD43546.1, ECO:0000313|Proteomes:UP000017929};
RN [1] {ECO:0000313|EMBL:CDD43546.1, ECO:0000313|Proteomes:UP000017929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:299 {ECO:0000313|Proteomes:UP000017929};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363032};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363032}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000256|RuleBase:RU363032}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the OsmX family.
CC {ECO:0000256|ARBA:ARBA00035642}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the binding-protein-
CC dependent transport system permease family.
CC {ECO:0000256|ARBA:ARBA00035652}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD43546.1}.
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DR EMBL; CBGZ010000225; CDD43546.1; -; Genomic_DNA.
DR AlphaFoldDB; R6ZR83; -.
DR STRING; 1262792.BN593_02093; -.
DR Proteomes; UP000017929; Unassembled WGS sequence.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd13609; PBP2_Opu_like_1; 1.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30177; GLYCINE BETAINE/L-PROLINE TRANSPORT SYSTEM PERMEASE PROTEIN PROW; 1.
DR PANTHER; PTHR30177:SF4; OSMOPROTECTANT IMPORT PERMEASE PROTEIN OSMW; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF04069; OpuAC; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363032};
KW Reference proteome {ECO:0000313|Proteomes:UP000017929};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363032};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363032}; Transport {ECO:0000256|RuleBase:RU363032}.
FT TRANSMEM 31..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 60..84
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 90..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 139..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 185..212
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363032"
FT DOMAIN 25..204
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50928"
SQ SEQUENCE 529 AA; 57680 MW; A7D3BBA60003DC14 CRC64;
MGVMEGMKEL LNYFVSSKEE VLSLLIEHIE LTVLALLAAI LIGVPLGILI SYIRPASKPV
LAFANIVQAV PSMALLGLAI PVFGIGMKPA IFLVVIYSLL PIIKNTYAGL MNINEQMLEA
AEGIGLTKSQ ILFKVRLPMA LPVIMTGVRI SAVSAVGLMT LAAYVGGGGL GYLVFSGIRT
VSNVMILAGA IPACILALLV DRVFAAIETI VTPVSLLDGK NKDEKRRRKK REMFVIATAV
VLLIALLFTS LFQTKKTADI RIASMDFTEN EIFAYMLSES IERELGLDVE TTPDLGAGSV
CMSSIQSNEI DGYVDYTGTL YVNILKNPAS SDVEQVYQDS VKGMKEQYGL EVLNSLNVNN
TYTLSTTKEL AEQYSLKTIS DLKSLPQPVT ICSTLAFMNR EDGLLGVEDK YGFQFDKKGV
DGSARYTALM NGEGQVIDAY STDGLLKKFD LAVLEDDAGV FPPYYAVPVF RGEIMEKYPE
IREITEQLAS VLSTDVMAGL NYLVDEEGQK PQDVAHEFLQ ENLPEYASK
//
