ID   R7AWM8_9FIRM            Unreviewed;       380 AA.
AC   R7AWM8;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Cation diffusion facilitator family transporter {ECO:0000313|EMBL:CDD46732.1};
GN   ORFNames=BN699_02243 {ECO:0000313|EMBL:CDD46732.1};
OS   Firmicutes bacterium CAG:534.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263027 {ECO:0000313|EMBL:CDD46732.1, ECO:0000313|Proteomes:UP000018220};
RN   [1] {ECO:0000313|EMBL:CDD46732.1, ECO:0000313|Proteomes:UP000018220}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:534 {ECO:0000313|Proteomes:UP000018220};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD46732.1}.
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DR   EMBL; CBHC010000072; CDD46732.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7AWM8; -.
DR   STRING; 1263027.BN699_02243; -.
DR   Proteomes; UP000018220; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR   Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR   InterPro; IPR002524; Cation_efflux.
DR   InterPro; IPR027470; Cation_efflux_CTD.
DR   InterPro; IPR036837; Cation_efflux_CTD_sf.
DR   InterPro; IPR027469; Cation_efflux_TMD_sf.
DR   NCBIfam; TIGR01297; CDF; 1.
DR   PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR   PANTHER; PTHR43840:SF15; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR   Pfam; PF01545; Cation_efflux; 1.
DR   Pfam; PF16916; ZT_dimer; 1.
DR   SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR   SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018220};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        86..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          218..293
FT                   /note="Cation efflux protein cytoplasmic"
FT                   /evidence="ECO:0000259|Pfam:PF16916"
SQ   SEQUENCE   380 AA;  42199 MW;  83290396E1406DCB CRC64;
     MKKWKEKRDS RAAMGKLSGL IGILCNLLLS GSKLLVGTMA ASMSITADGL NNLSDAASSI
     VTLAGFKLAE KPADKEHPYG HARFEYLASL TVSVMILVIG FELAKSSVEK LLHPAEIVFS
     ALSVWVLVLS ILVKAGMMVF NGKMGKRLQS TALLATAADS RNDVLTTGAV LIATVTEHFT
     GLKIDGVMGI LVALFILCSG IKLAKETVSP LLGEGVNPDL RKQLTDYINS CPMILGCHDL
     MVHDYGPGRR YASIHVEMDC HVDAMVAHEQ IDRMERECLE EFETHMVIHY DPVITDNAEL
     DRLRELVSSL LREKDERLSL HDFRLICHEH EKLLLFDVMI PDEFQGQEES LKGYLEAALL
     QQEKERYRLE ITFDLETDEA
//