ID   R7BIM3_9FIRM            Unreviewed;      1411 AA.
AC   R7BIM3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=CoA-substrate-specific enzyme activase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN803_02370 {ECO:0000313|EMBL:CDD65671.1};
OS   Firmicutes bacterium CAG:882.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1262991 {ECO:0000313|EMBL:CDD65671.1, ECO:0000313|Proteomes:UP000017928};
RN   [1] {ECO:0000313|EMBL:CDD65671.1, ECO:0000313|Proteomes:UP000017928}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:882 {ECO:0000313|Proteomes:UP000017928};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD65671.1}.
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DR   EMBL; CBHL010000089; CDD65671.1; -; Genomic_DNA.
DR   Proteomes; UP000017928; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 1.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017928}.
FT   DOMAIN          8..258
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          322..576
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          671..890
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   1411 AA;  155580 MW;  8931D06CE5071A89 CRC64;
     MTTSEYRLGI DIGSTTVKIA IIDKDNNILF SDYERHFANI QETLAGLLVK AKEKLGAIKV
     HPVITGSGGL TLASHLEVPF TQEVVAVSTA LSDYAPQTDV AIELGGEDAK IIYFTNGIDQ
     RMNGICAGGT GSFIDQMATL LQTDATGLNE YAKNYQAIYP IAARCGVFAK SDIQPLINEG
     ATKEDLSASI FQAVVNQTIS GLACGKPIRG NVAFLGGPLH FLSELKNAFI RTLNLGPENI
     IAPEHSHLFA AVGSAMTAKD EIAIDIDALI TKLHNKIKMD FEVERMEPLF ASEDAYKEFR
     ARHDSHCVVK GSLKDYSGNC YLGIDAGSTT TKAAVVAEDG TLLYSFYSSN NGSPLATSIK
     AIKEIYSLLP ADAHIVRSCS TGYGEALIKS ALMLDEGEVE TVSHYYAAAF FDPAVDCILD
     IGGQDMKCIK IKNNTVDSVQ LNEACSSGCG SFIETFAKSL NYSVEDFAKE ALFAPHPIDL
     GTRCTVFMNS KVKQAQKEGA SVADISAGLA YSVIKNALYK VIKIADPKDL GHQIVVQGGT
     FYNDAVLRSL EKITGVEVIR PDIAGIMGAF GAALVARERY EGQETTMLSI DKINELTYET
     RMARCKGCTN SCLLTINRFS GGRQFISGNR CERGIGKEKN KDHVPNLFEY KNKRLFSYEP
     LEITDATRGV VGIPRVLNMY ENYPFWFTFF TKLGFRVVLS PESSRKIYEL GIESIPSESE
     CYPAKLAHGH VSWLIKQGVK FIFYPCIPYE RKEIDNTNNH YNCPIVTSYA ENIKNNVEEL
     VTENILFMNP FLSFADEKVL AKRLAKEVGA QFNIPSGEIA NACHAAWEEL AACRADVMKK
     GEETLKYLEE TGRHAIVLAG RPYHIDPEIN HGIPELINSY GIAVLTEDSI SHLGKVERPL
     IVMDQWMYHS RLYAAASFIR DKDNIDMIQL NSFGCGLDAV TTDQVNDILS SAGKIYTVLK
     IDEVNNLGAA RIRIRSLISA IKVRERNNYQ RKITSSAYHR TEFTKEMRDQ NYTILCPQMS
     PIHFDLIEPA LNSCGYNVEV LKNVSKSAVD TGLKYVNNDA CYPSLIVVGQ MMEAVLSGKY
     DLNKTALVIT QTGGGCRASN YIGFIRRALI KAGYPNIPVI SLSVQGLETN SGFTYTLPMI
     KKAAMAIQYG DIFMNVVYRT RPYEAVPGSA NALHEKWKKI IIEQLTQPKV YMKDFNRNIK
     QIIKEFDELP LLDIKKPRVG VVGEILVKFM PAANNYLVDL LEKEGAEAVV PDFMGFMLYC
     AENANFKSEH LGASRKSMHL SNAVIKAINL FRGASNKALA QSKRFDPPTD IKEMTKMAAP
     LVSLGNQTGE GWLLTAEMIE LIHHGAKNIV CCQPFACLPN HIVGKGVIKE LRAAYPDANI
     IAVDYDPGAS EVNQLNRIKL MLSTAQKNLE K
//