ID   R7BQG7_9ACTN            Unreviewed;       460 AA.
AC   R7BQG7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   ORFNames=BN629_00418 {ECO:0000313|EMBL:CDD68076.1};
OS   Eggerthella sp. CAG:368.
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Eggerthella.
OX   NCBI_TaxID=1262877 {ECO:0000313|EMBL:CDD68076.1, ECO:0000313|Proteomes:UP000018088};
RN   [1] {ECO:0000313|EMBL:CDD68076.1, ECO:0000313|Proteomes:UP000018088}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:368 {ECO:0000313|Proteomes:UP000018088};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492,
CC       ECO:0000256|RuleBase:RU003345}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD68076.1}.
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DR   EMBL; CBHM010000136; CDD68076.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7BQG7; -.
DR   STRING; 1262877.BN629_00418; -.
DR   Proteomes; UP000018088; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   CDD; cd07136; ALDH_YwdH-P39616; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|PIRNR:PIRNR036492};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018088}.
FT   DOMAIN          2..430
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        212
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        246
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   460 AA;  50986 MW;  D7C5B4E4A478382E CRC64;
     MTSEEIQVIL EKQRAFFNSG ATIPVDFRIA ALRKLYAAIR THEDEIHAAL TADLGKSNYE
     GFMCESGLAL TEISYMIKHT RKLARPKTVH TPLAQFASHS FTQAVPYGNT LIMSPWNYPF
     LLTIDPLADA IAAGNTVVLK PSAYSPATSK IIATIVSECF PPEYVAIVTG GRAENTALLK
     QKFDFIFFTG SQTVGKEVLR HAAEHLTPIV LELGGKSPCI VDASANVKLA AKRIVFGKFL
     NCGQTCVAPD YILVERSIHD QLITELKRQI ELQFGKNPIE NTGYGKIVNQ KHFERLYSLI
     DTNKVVYGGQ TDETSCRIAP TVMDGVMAED AVMGEEIFGP LLPVLTFDSF DQVVRGLQNK
     AKPLAMYLFS SNKNHIDQYR RELSFGGGCI NDVVIHLATS EMAFGGVGES GMGAYHGKRG
     FEAFSHLKSI VDKKTWIDLP MRYQPYTSKL YNKLLHVFLR
//