ID R7C936_9CLOT Unreviewed; 712 AA.
AC R7C936;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Subtilase {ECO:0000313|EMBL:CDD73828.1};
GN ORFNames=BN737_02419 {ECO:0000313|EMBL:CDD73828.1};
OS Clostridium sp. CAG:62.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262828 {ECO:0000313|EMBL:CDD73828.1, ECO:0000313|Proteomes:UP000018137};
RN [1] {ECO:0000313|EMBL:CDD73828.1, ECO:0000313|Proteomes:UP000018137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:62 {ECO:0000313|Proteomes:UP000018137};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD73828.1}.
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DR EMBL; CBHQ010000051; CDD73828.1; -; Genomic_DNA.
DR AlphaFoldDB; R7C936; -.
DR MEROPS; S08.105; -.
DR Proteomes; UP000018137; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000018137};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 166..406
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 174
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 208
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 361
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 712 AA; 79582 MW; E280C67C196EDA15 CRC64;
MRVREIMRRS CAVTAMAALV MHHVGPMLNI RAAEPANESG VTGQRTQQKG KKDYIVKFKT
KAEMKQSTKT YEESTEINQN GEDKLEENKL VSLELSGKEA EQLETNQNVE FVEEDKEVSA
CGEKYFAGKD KKKHKKVEKR HKKNESKVEW NVQMIHAENK AKKSNNKVKI AILDSGVDWG
NDIDLAYQTS LVPGEEEMTQ MFMDGSGHGS SVASLIAAKD NGEGITGINP NAEIYSYRVL
GDGNKAPISR VVEAIYMAIN HKVNIINMSF GISEYSETLE KAVQDAADAG ILVVAAAGNT
GSEGVQYPAA YDEVMAVGAV DKDGSVEQYS AKGEELDLVA PGELVRTTGF IGSEEVVSGT
SLAAPQVAAA ASLIMEKNLN ASPEFVRGLL NETANLYGES DAYGSGLLDA EYALAQYDNY
SKNYTKINTQ NGVEVKVNKR KVETFEDTGC VAGSWTEGAH KKMVEEEYYC VRAGVRFPDL
KEKQPTIDYE GKSWNLNLGS NTSDDKYLFY GHKFNPCWHG YYTTNYVKAV LYATYIAEAV
YKYNTIARTE SSFEYEYAQR MQQSVEHLYD KSQEGWNYIL YDLKKNNSKA KKQSNSNGFK
RAVIWGMAIH SATDVYAHST RTRSGDIIHP STGIKNGADD KEYIKERYDD AATVARRMML
RYSEKKELRV TDLEVPGNYT RNYELNKYSD YMKEVGNEVH YTFDYSNSHG TK
//
