ID R7CCV1_9CLOT Unreviewed; 453 AA.
AC R7CCV1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN ORFNames=BN737_01335 {ECO:0000313|EMBL:CDD75148.1};
OS Clostridium sp. CAG:62.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262828 {ECO:0000313|EMBL:CDD75148.1, ECO:0000313|Proteomes:UP000018137};
RN [1] {ECO:0000313|EMBL:CDD75148.1, ECO:0000313|Proteomes:UP000018137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:62 {ECO:0000313|Proteomes:UP000018137};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD75148.1}.
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DR EMBL; CBHQ010000134; CDD75148.1; -; Genomic_DNA.
DR AlphaFoldDB; R7CCV1; -.
DR Proteomes; UP000018137; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd13143; MATE_MepA_like; 1.
DR InterPro; IPR002528; MATE_fam.
DR InterPro; IPR045070; MATE_MepA-like.
DR InterPro; IPR048279; MdtK-like.
DR PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 453 AA; 49133 MW; F62B6F2C5C9CF2D4 CRC64;
MNKETNNPLG VQPVNRLLSQ FAIPSIISML VGSLYNIVDQ FFIGQRVGEL GNAATNIAFP
LSTSCLALAL LIGIGGSSAF NLAMGSGHEK RAVNIMGNAV VLLAGSGLVL SIITLLFLKP
LLLFFGSPKA VLPYAMEYTK ITAFGFPFLL LSTGGGHLIR ADGRPRITML CNLVGAVLNT
ILDALFVFGL NLGMSGAALA TIIGQIVSGA LAIGYLMHGK TVTIRRENLR IKWENVTRIA
SLGMAPCSNQ VAMMVVQIIM NQSLKHYGSH SIYGENIPIA CAGIITKVNM IFMSFVIGLS
QGLQPIASFN YGAGKKGRVK EAYIKAISIG AVLAVIAFLM FQFFPRQIIS IFGDGSELYY
QFAIRYFHVF LFFTFVNFMQ PITSNFFTAI GKPKVGSFLA LTRQILFLLP LILLFPLFLG
IDGIMYAGPV ADCLAAVVCF IMVYRELRNF NQK
//
