ID R7CWA2_9BACE Unreviewed; 880 AA.
AC R7CWA2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN666_01120 {ECO:0000313|EMBL:CDD81683.1};
OS Bacteroides sp. CAG:462.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262740 {ECO:0000313|EMBL:CDD81683.1, ECO:0000313|Proteomes:UP000018063};
RN [1] {ECO:0000313|EMBL:CDD81683.1, ECO:0000313|Proteomes:UP000018063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:462 {ECO:0000313|Proteomes:UP000018063};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00560}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD81683.1}.
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DR EMBL; CBHU010000019; CDD81683.1; -; Genomic_DNA.
DR AlphaFoldDB; R7CWA2; -.
DR STRING; 1262740.BN666_01120; -.
DR Proteomes; UP000018063; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018063}.
FT DOMAIN 1..289
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 319..559
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
SQ SEQUENCE 880 AA; 101435 MW; 350CB7D6D0CFCB32 CRC64;
MSGEIKSFGL NIFDETYIEK GDGLRAKLAD PQTIPAYRKL LEALRDEATD VMHSIADQFF
GILEAEGLRP DDLAGKSRGI ASYFKKLRDG KWGDDIRNST VEKCLDSADN WAAKTSPRRS
EIIALASAQL QPLLVEAEKQ RPEQGRTLNS CELSLRYLNQ LRLLANIDEE VRALNRRENR
FLLSDTNALL RRLMQEGDSS FVFEKIGTTL RHVMIDEFQD TSRMQWNNFK MLLLEGLSQG
AGSLIVGDVK QSIYRWRNGD WSILNNLRGK MEGIYPIREM KLTTNRRSES NIIRFNNDIF
TAGSAWLNEI YRNTYGTDCT ELQQAYSDVC QDSPRKEEKG YVHVDFLIPE DNEDYVEMTL
ECLAEQVEKL VSEGVRLEDI TILVRKNKNI PVIADYFSAN LPYRIVSDEA FRLDASSCVC
ALIDCLRWLA DETDTIALAR LAAMYQREIV GSDTDWNTLL LQGAEHYVPQ DFITRREELR
LMPLYELLEH LFTLFGMAER EDQDAYLFAF FDAVIEYLQE NSSDLDSFLA WWDDKLCAKT
IPSGELEGIR IYSIHKSKGL EFHTVLIPFC DWSLENEIRT QMIWCTPQDS PYNELDLVPV
NYGANMANST YEQDYRHERV QLWVDNLNLL YVAFTRAGKN LFVWAKDGQS NSISTLLYHS
LCRIDPAFEG MGEFETGTLC PSVEKEERQA GNNRLTAQPG TRLVKMASFD NRIDFRQSNR
SADFIRGEED EDDSQRYIRQ GRLLHYVFAT IRTRDDVEPT LAQMESEGLF DSAGDVGHAR
SLIQRALARP EARKWFDGSC ELFNECSIVY MENGELQTRR PDRVMIDGGQ VVVVDFKFGK
QSPTYHEQVR GYMQLLRRMG YTDVRGYLWY IYKNELITVE
//
