ID R7CZM1_9BACE Unreviewed; 558 AA.
AC R7CZM1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Glycoside hydrolase family 43 {ECO:0000313|EMBL:CDD82982.1};
GN ORFNames=BN666_02286 {ECO:0000313|EMBL:CDD82982.1};
OS Bacteroides sp. CAG:462.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262740 {ECO:0000313|EMBL:CDD82982.1, ECO:0000313|Proteomes:UP000018063};
RN [1] {ECO:0000313|EMBL:CDD82982.1, ECO:0000313|Proteomes:UP000018063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:462 {ECO:0000313|Proteomes:UP000018063};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD82982.1}.
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DR EMBL; CBHU010000137; CDD82982.1; -; Genomic_DNA.
DR AlphaFoldDB; R7CZM1; -.
DR STRING; 1262740.BN666_02286; -.
DR Proteomes; UP000018063; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09001; GH43_FsAxh1-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF13; HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000018063};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..558
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004442467"
FT DOMAIN 345..556
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT ACT_SITE 51
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 217
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 159
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 558 AA; 62414 MW; 6FBEEE85C63B6467 CRC64;
MKRKTLLGTL LLAIALPLAA QQAEPYRSQV WVPDQGDGTY KNPVLYADYS DPDACRVGDD
FYMTSSSFNC VPGLQILHSK DLVNWTIIGA AVPYAVPPVT DTKPEHGNRI WAPCIRHHDG
EFYIFWGDPD QGAFMVKAKD PRGPWSEPVL VKPGVGIIDT TPLWDDDGRV YMAHAYAGSR
AQLKSVIAVC ELNADATKAI TPSRIVFDGH EGQGTCEGPK FYKRNGYYYI FHPAGGVPTG
FQTVQRSKNV YGPYENRIVL AQGKSPVNGP HQGAWVDTPT GEDWFLHFQD VGAYGRLVHL
QPMKWVNDWP VIGNDEDGDG CGDPVLTYRK PNVGQTYPIC TPQESDEFDG LVLGPQWQWQ
ANFNEKWLYC AGDKGYLRLY SYPVGEDYKN LRDVSNLLMQ KTTGPSQTIT TKMTFKPTEK
YKGERVGLTV FGRDYAALIV ENTDNGLVLS QVECMKADKG SAEKVNGKVT LKENTFYLRA
RIYDTEKKIK GSEGGHDQVV MCEFSYSTNG KKYHSLGKPF QVREGQWIGA KHGIFCARPH
IVTNDGGWVD VDWYRVTK
//
