ID   R7D097_9BACE            Unreviewed;       447 AA.
AC   R7D097;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN   ORFNames=BN666_02495 {ECO:0000313|EMBL:CDD83197.1};
OS   Bacteroides sp. CAG:462.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=1262740 {ECO:0000313|EMBL:CDD83197.1, ECO:0000313|Proteomes:UP000018063};
RN   [1] {ECO:0000313|EMBL:CDD83197.1, ECO:0000313|Proteomes:UP000018063}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:462 {ECO:0000313|Proteomes:UP000018063};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC       {ECO:0000256|ARBA:ARBA00005163}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD83197.1}.
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DR   EMBL; CBHU010000158; CDD83197.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7D097; -.
DR   STRING; 1262740.BN666_02495; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000018063; Unassembled WGS sequence.
DR   GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018063};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001369}.
FT   ACT_SITE        324
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        383
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   447 AA;  50893 MW;  7CD216F65B914AE3 CRC64;
     MKKEYLVYKL SEDVKDCTRI DTELFSKYDV KRGLRNEDGT GVLVGLTKIG NVVGYERIPG
     GGLKPIPGKL YYRGYDLEDI AGNILKEKRF GFEEVAYLML SGKLPDKEEL ANFKELINEN
     MPLEQKTKMN IIELEGTNIM NILARSVLEM YRFDPKADDT SRDNLVRQSI ELISKFPTII
     AYAYNMLRHA TFGRSLHIRH PQENLSIAEN FLYMLKHRYT ELDARMLDLL LVLQAEHGGG
     NNSTFTVRVT SSTGTDTYSA IAAGIGSLKG PLHGGANLQA AAMFDHLKEA IHDWTNADEI
     DTYFTRMLNK EVYDRKGLIY GIGHAVYTIS DPRALLLKDL AHALAKEKGR EEEFAFLELL
     EERAIDTFYR VKNNGKTVSS NIDFFSGFIY ELIGLPREIY TPLFAMARIV GWCAHRNEEL
     NFEGKRIIRP AYKNVLDTVE YVPLAQR
//