ID R7D0Y4_9BACE Unreviewed; 719 AA.
AC R7D0Y4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Ribonuclease R {ECO:0000256|HAMAP-Rule:MF_01895};
DE Short=RNase R {ECO:0000256|HAMAP-Rule:MF_01895};
DE EC=3.1.13.1 {ECO:0000256|HAMAP-Rule:MF_01895};
GN Name=rnr {ECO:0000256|HAMAP-Rule:MF_01895};
GN ORFNames=BN666_02647 {ECO:0000313|EMBL:CDD83363.1};
OS Bacteroides sp. CAG:462.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262740 {ECO:0000313|EMBL:CDD83363.1, ECO:0000313|Proteomes:UP000018063};
RN [1] {ECO:0000313|EMBL:CDD83363.1, ECO:0000313|Proteomes:UP000018063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:462 {ECO:0000313|Proteomes:UP000018063};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside
CC monophosphates and is involved in maturation of structured RNAs.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.13.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001849, ECO:0000256|HAMAP-
CC Rule:MF_01895};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01895}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD83363.1}.
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DR EMBL; CBHU010000173; CDD83363.1; -; Genomic_DNA.
DR AlphaFoldDB; R7D0Y4; -.
DR STRING; 1262740.BN666_02647; -.
DR Proteomes; UP000018063; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008859; F:exoribonuclease II activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016070; P:RNA metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04471; S1_RNase_R; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR HAMAP; MF_01895; RNase_R; 1.
DR InterPro; IPR040476; CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR004476; RNase_II/RNase_R.
DR InterPro; IPR011805; RNase_R.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00358; 3_prime_RNase; 1.
DR NCBIfam; TIGR02063; RNase_R; 1.
DR PANTHER; PTHR23355:SF9; DIS3-LIKE EXONUCLEASE 2; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17876; CSD2; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00955; RNB; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01895};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_01895};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_01895};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_01895};
KW Reference proteome {ECO:0000313|Proteomes:UP000018063};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_01895}.
FT DOMAIN 638..719
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 719 AA; 82666 MW; C58D6C4E50C4267E CRC64;
MGKKDKKVKK EKKGGKRMTK KQLVEKLTDL IQLNAPESVS LKRIYAELKL NTHPLKMLCL
DILQDMLTDD FICEPEKGRY KLKNPDQIVT GTFQRKSNGK NSLLPEDGST PIFVAERNSA
HAMNNDKVRV ALFARRKNRE REGEVIEILE RANDTFVGRL KVDRHYAFLL TESRTLANDI
FIPKERLKGA KDGDKVVVRV AEWPDDAKNP IGQVIDVLGR AGDNTTEMHA ILAEYGLPYS
YPENVEHAAE QIPAEISAED LAEREDFRDV LTFTIDPKDA KDFDDALSIR RVNDGLWEVG
VHIADVSHYV KEGSIIDKEA FKRATSVYLV DRTVPMLPER LCNFICSLRP DEEKLAYSVI
FRIDDKGNVR DSHIAHTVIR SNRRFTYEEV QDILEARQGE YAAELMQLNT FAKILRERRM
AAGAINFDRM EVRFEIDEAT GRPLSVYFKV QKDAHKLIEE FMLLANRTVA ERIGKVRGGA
KPKVFPYRIH DLPDPEKLED LKNFIVKFGY KLKTAGSKTD VSRSLNHLLD EIQGKKEENL
IETVSLRAMQ KARYSTFNIG HYGLAFDYYT HFTSPIRRYP DLMVHRLLTR YLAGGRSVQQ
QKYEDKCEHC SDMEQVAASA ERASIKYKQV EFMSEHIGEV YDGTISGITE WGIYVEINEN
KCEGMVPMRD LGEDYYDFDE KNYCLIGRKR HKRFSLGDPV RIKVARANLE KKQLDFTIA
//
