ID   R7D9Z4_9ACTN            Unreviewed;       745 AA.
AC   R7D9Z4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Integrase catalytic region {ECO:0000313|EMBL:CDD86668.1};
GN   ORFNames=BN589_01203 {ECO:0000313|EMBL:CDD86668.1};
OS   Collinsella sp. CAG:289.
OC   Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales;
OC   Coriobacteriaceae; Collinsella.
OX   NCBI_TaxID=1262851 {ECO:0000313|EMBL:CDD86668.1, ECO:0000313|Proteomes:UP000017952};
RN   [1] {ECO:0000313|EMBL:CDD86668.1, ECO:0000313|Proteomes:UP000017952}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:289 {ECO:0000313|Proteomes:UP000017952};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD86668.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CBHV010000118; CDD86668.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7D9Z4; -.
DR   Proteomes; UP000017952; Unassembled WGS sequence.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR025948; HTH-like_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR011646; KAP_P-loop.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR048020; Transpos_IS3.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   NCBIfam; NF033516; transpos_IS3; 1.
DR   PANTHER; PTHR46889; TRANSPOSASE INSF FOR INSERTION SEQUENCE IS3B-RELATED; 1.
DR   PANTHER; PTHR46889:SF1; TRANSPOSASE INSO FOR INSERTION SEQUENCE ELEMENT IS911B-RELATED; 1.
DR   Pfam; PF13276; HTH_21; 1.
DR   Pfam; PF07693; KAP_NTPase; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF13333; rve_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   SUPFAM; SSF48295; TrpR-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017952}.
FT   DOMAIN          578..742
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   COILED          402..429
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   745 AA;  83528 MW;  CBD5A55A3DBBD280 CRC64;
     MDNSNLSLAT DTPIKAREQD LIGRIPFAER LAGILKSAAG PESLVIGLYG PWGSGKTSVI
     NLVENALSRK NDDGKAGVSV VRFEPWNYLT AEQLLAQFLK EVGGALDKDA HGRRTLFSKL
     RGKRPEVLNA FAAYSEALII TAGAAASLAG APLAGVAVPA FGNRLASKLR KSADRAGSVS
     AEKQRLEEEL LCLCQVGNEQ WGLRWESWTK SEQEGSRMYS AEQRKIAIET FVKFDHSYAD
     TIAELGYPTR ACLRNWWNEY RDTGEVPISK FTTNPRYTAE MRRRAVEHYL EHGKSLTRTM
     RALGYPKSRE VLGDWIDEIA PGQRKYRGPN PKRDPVPVEK KVQVVAELEA RSGPAAEIAE
     RHGVSRTAPY IWRREIMGDN GGDPEKKGVP VSKEYDDLPD DIEVLQGMLR EAKMQLRKVQ
     LELEVRQATL EIVKKDPGAE PGLLTNAEKA AMVTALRPRW KLCEVLPVVG MAKSSYEYAR
     SAQARGETEE HAAARKAVIE AFEASGGTYG YRRIYARVNA DVEDGEAIGE WTVRSIMEEE
     NLVARAAKKK RRYSSYEGEI SEAPPNLLRD DRGKHHFRAN KPNELWITDV TEFRIPAGKV
     YLSPIVDCFD GMPLSWSIST SPDAEMANSS LLGACEWLGE GDHPKIHSDR GCHYRWPEWI
     RICDENGLVR SMSRKGCSPD NARCEGYFGR LKIEFFHGCD WAGVTIEEFM GMLDAYLRWY
     RDVRIKGDLD YRSPMQYRRD LGLAA
//